2021 Atlantic Coast Conference Leaders Scoring Defense - Games in November Only through 01/10/2022
| Name | G | TD | FG | 1XP | 2XP | Safety | Points | Points/G | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Clemson | 4 | 7 | 3 | 5 | 1 | 0 | 58 | 14.5 |
| 2 | Miami (Florida) | 4 | 11 | 6 | 9 | 2 | 0 | 97 | 24.3 |
| 3 | Boston College | 4 | 12 | 5 | 11 | 0 | 1 | 100 | 25.0 |
| 3 | Louisville | 4 | 12 | 8 | 11 | 0 | 0 | 107 | 26.8 |
| 5 | Virginia Tech | 4 | 12 | 4 | 12 | 0 | 0 | 96 | 24.0 |
| 5 | Pittsburgh | 4 | 13 | 4 | 12 | 0 | 1 | 104 | 26.0 |
| 7 | Florida State | 4 | 14 | 2 | 13 | 0 | 0 | 103 | 25.8 |
| 7 | North Carolina State | 4 | 13 | 5 | 13 | 0 | 0 | 106 | 26.5 |
| 7 | Virginia | 3 | 13 | 4 | 13 | 0 | 1 | 105 | 35.0 |
| 10 | Syracuse | 3 | 14 | 5 | 14 | 0 | 0 | 113 | 37.7 |
| 11 | North Carolina | 4 | 18 | 3 | 16 | 0 | 0 | 133 | 33.3 |
| 12 | Wake Forest | 4 | 19 | 8 | 18 | 1 | 0 | 158 | 39.5 |
| 13 | Georgia Tech | 4 | 22 | 7 | 21 | 0 | 0 | 174 | 43.5 |
| 14 | Duke | 4 | 26 | 10 | 25 | 0 | 0 | 211 | 52.8 |