2021 Atlantic Coast Conference Leaders Rushing Defense - Games vs. Unranked Teams Only (AP Poll) through 01/10/2022
| Name | G | Att | Yards | Avg. | TD | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Louisville | 8 | 273 | 1141 | 4.18 | 9 | 34.13 | 142.63 |
| 2 | Clemson | 9 | 284 | 785 | 2.76 | 5 | 31.56 | 87.22 |
| 3 | Syracuse | 8 | 300 | 1082 | 3.61 | 8 | 37.50 | 135.25 |
| 4 | Virginia | 8 | 301 | 1704 | 5.66 | 12 | 37.63 | 213.00 |
| 5 | Florida State | 8 | 304 | 1171 | 3.85 | 10 | 38.00 | 146.38 |
| 6 | Miami (Florida) | 8 | 305 | 1149 | 3.77 | 12 | 38.13 | 143.63 |
| 7 | Boston College | 9 | 323 | 1505 | 4.66 | 12 | 35.89 | 167.22 |
| 8 | North Carolina State | 10 | 324 | 1260 | 3.89 | 5 | 32.40 | 126.00 |
| 9 | Georgia Tech | 8 | 345 | 1425 | 4.13 | 10 | 43.13 | 178.13 |
| 10 | North Carolina | 9 | 363 | 1619 | 4.46 | 17 | 40.33 | 179.89 |
| 11 | Pittsburgh | 11 | 367 | 947 | 2.58 | 12 | 33.36 | 86.09 |
| 12 | Duke | 10 | 384 | 1984 | 5.17 | 20 | 38.40 | 198.40 |
| 13 | Virginia Tech | 11 | 394 | 1810 | 4.59 | 16 | 35.82 | 164.55 |
| 14 | Wake Forest | 11 | 453 | 2219 | 4.90 | 18 | 41.18 | 201.73 |