2021 Atlantic Coast Conference Leaders Rushing Defense - From Own 39 To 21 Yard Line through 01/10/2022
| Name | G | Att | Yards | Avg. | TD | Long | 1st | 10+ | 20+ | |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Pittsburgh | 14 | 64 | 149 | 2.33 | 0 | 20 | 12 | 5 | 1 |
| 2 | Clemson | 13 | 70 | 222 | 3.17 | 2 | 27 | 13 | 9 | 3 |
| 3 | North Carolina State | 12 | 63 | 213 | 3.38 | 0 | 22 | 12 | 10 | 2 |
| 4 | Syracuse | 12 | 66 | 237 | 3.59 | 0 | 28 | 18 | 8 | 3 |
| 5 | Florida State | 12 | 78 | 302 | 3.87 | 1 | 22 | 18 | 11 | 2 |
| 6 | Miami (Florida) | 12 | 70 | 294 | 4.20 | 4 | 30 | 17 | 9 | 5 |
| 7 | Boston College | 12 | 84 | 364 | 4.33 | 0 | 28 | 22 | 9 | 5 |
| 8 | Virginia Tech | 12 | 88 | 385 | 4.38 | 2 | 28 | 26 | 13 | 5 |
| 9 | Louisville | 13 | 98 | 443 | 4.52 | 2 | 35 | 23 | 13 | 4 |
| 10 | Duke | 11 | 73 | 346 | 4.74 | 4 | 36 | 24 | 15 | 6 |
| 11 | Wake Forest | 14 | 100 | 481 | 4.81 | 2 | 24 | 28 | 21 | 4 |
| 12 | Georgia Tech | 12 | 84 | 445 | 5.30 | 3 | 35 | 26 | 13 | 3 |
| 13 | North Carolina | 13 | 90 | 482 | 5.36 | 3 | 38 | 29 | 17 | 7 |
| 14 | Virginia | 12 | 88 | 534 | 6.07 | 4 | 31 | 29 | 19 | 6 |
| 1st: First Downs; 10+: Rush attempts of 10 or more yards; 20+: Rush attempts of 20 or more yards | ||||||||||