2021 Atlantic Coast Conference Leaders Rushing Defense - In The 2nd Quarter through 01/10/2022
| Name | G | Att | Yards | Avg. | TD | Long | 1st | 10+ | 20+ | |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Louisville | 13 | 96 | 332 | 3.46 | 5 | 27 | 20 | 11 | 3 |
| 2 | North Carolina State | 12 | 102 | 355 | 3.48 | 4 | 55 | 18 | 11 | 4 |
| 3 | Miami (Florida) | 12 | 115 | 464 | 4.03 | 3 | 29 | 28 | 22 | 5 |
| 3 | Duke | 12 | 115 | 708 | 6.16 | 11 | 72 | 29 | 22 | 8 |
| 5 | Virginia Tech | 13 | 116 | 473 | 4.08 | 7 | 29 | 28 | 18 | 3 |
| 6 | Georgia Tech | 12 | 117 | 459 | 3.92 | 6 | 45 | 26 | 12 | 3 |
| 6 | Boston College | 12 | 117 | 536 | 4.58 | 3 | 33 | 30 | 20 | 6 |
| 6 | Virginia | 12 | 117 | 574 | 4.91 | 5 | 63 | 26 | 16 | 6 |
| 9 | Syracuse | 12 | 118 | 271 | 2.30 | 4 | 38 | 21 | 9 | 2 |
| 9 | Clemson | 13 | 118 | 292 | 2.47 | 2 | 39 | 19 | 7 | 3 |
| 11 | Pittsburgh | 14 | 120 | 190 | 1.58 | 3 | 54 | 13 | 6 | 1 |
| 12 | Florida State | 12 | 129 | 561 | 4.35 | 5 | 63 | 33 | 16 | 4 |
| 13 | North Carolina | 13 | 135 | 526 | 3.90 | 6 | 53 | 33 | 15 | 5 |
| 14 | Wake Forest | 14 | 140 | 675 | 4.82 | 5 | 35 | 43 | 27 | 5 |
| 1st: First Downs; 10+: Rush attempts of 10 or more yards; 20+: Rush attempts of 20 or more yards | ||||||||||