2021 Big 12 Conference Leaders Passes Defended - Games vs. FBS non-Power 5 Conference Teams Only through 01/10/2022
| Name | G | Int. | Passes Broken Up | Passes Defended | Passes Defended/G | |
|---|---|---|---|---|---|---|
| 1 | Oklahoma State | 3 | 2 | 13 | 15 | 5.00 |
| 2 | Texas Tech | 2 | 5 | 9 | 14 | 7.00 |
| 3 | Baylor | 2 | 3 | 5 | 8 | 4.00 |
| 4 | Kansas State | 1 | 1 | 4 | 5 | 5.00 |
| 5 | TCU | 1 | 3 | 0 | 3 | 3.00 |
| 5 | Kansas | 1 | 0 | 3 | 3 | 3.00 |
| 5 | Texas | 2 | 0 | 3 | 3 | 1.50 |
| 8 | Oklahoma | 1 | 0 | 2 | 2 | 2.00 |
| 9 | Iowa State | 1 | 1 | 0 | 1 | 1.00 |