2021 Big 12 Conference Leaders Interceptions - Games vs. FBS non-Power 5 Conference Teams Only through 01/10/2022
| Name | G | Int. | Yards | TD | Int./G | |
|---|---|---|---|---|---|---|
| 1 | Texas Tech | 2 | 5 | 85 | 2 | 2.50 |
| 2 | Baylor | 2 | 3 | 40 | 1 | 1.50 |
| 3 | TCU | 1 | 3 | 52 | 0 | 3.00 |
| 3 | Oklahoma State | 3 | 2 | 11 | 0 | 0.67 |
| 3 | Kansas State | 1 | 1 | 26 | 0 | 1.00 |
| 3 | Iowa State | 1 | 1 | 5 | 0 | 1.00 |