2021 Big 12 Conference Leaders Tackles For Loss - Games in August/September Only through 01/10/2022
| Name | G | TFL | TFL Yards | TFL/G | |
|---|---|---|---|---|---|
| 1 | West Virginia | 4 | 35.0 | 134 | 8.75 |
| 2 | Oklahoma | 4 | 32.0 | 126 | 8.00 |
| 3 | Iowa State | 4 | 30.0 | 120 | 7.50 |
| 3 | Baylor | 4 | 30.0 | 79 | 7.50 |
| 5 | Oklahoma State | 4 | 29.0 | 129 | 7.25 |
| 6 | Texas Tech | 4 | 26.0 | 99 | 6.50 |
| 7 | Kansas State | 4 | 25.0 | 104 | 6.25 |
| 8 | Texas | 4 | 24.0 | 76 | 6.00 |
| 9 | TCU | 3 | 12.0 | 37 | 4.00 |
| 10 | Kansas | 4 | 12.0 | 31 | 3.00 |