2021 Big 12 Conference Leaders Rushing Offense - Games vs. Ranked Teams Only (AP Poll) through 01/10/2022
| Name | G | Att | Yards | Avg. | TD | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Baylor | 5 | 197 | 1048 | 5.32 | 9 | 39.40 | 209.60 |
| 2 | Oklahoma | 3 | 116 | 593 | 5.11 | 5 | 38.67 | 197.67 |
| 3 | TCU | 3 | 104 | 410 | 3.94 | 2 | 34.67 | 136.67 |
| 4 | Texas | 5 | 172 | 676 | 3.93 | 9 | 34.40 | 135.20 |
| 5 | Oklahoma State | 4 | 179 | 659 | 3.68 | 6 | 44.75 | 164.75 |
| 6 | Kansas State | 3 | 73 | 267 | 3.66 | 1 | 24.33 | 89.00 |
| 7 | Texas Tech | 4 | 114 | 398 | 3.49 | 5 | 28.50 | 99.50 |
| 8 | Kansas | 3 | 108 | 374 | 3.46 | 2 | 36.00 | 124.67 |
| 9 | Iowa State | 5 | 156 | 487 | 3.12 | 5 | 31.20 | 97.40 |
| 10 | West Virginia | 3 | 100 | 174 | 1.74 | 2 | 33.33 | 58.00 |