2021 Big 12 Conference Leaders Opponent Penalties - Games in October Only through 01/10/2022
| Name | G | Pen. | Yards | Pen./G | Yards/G | |
|---|---|---|---|---|---|---|
| 1 | Texas Tech | 5 | 32 | 281 | 6.4 | 56.2 |
| 2 | Oklahoma | 5 | 33 | 279 | 6.6 | 55.8 |
| 2 | Oklahoma State | 4 | 26 | 223 | 6.5 | 55.8 |
| 4 | Kansas State | 4 | 25 | 204 | 6.3 | 51.0 |
| 5 | TCU | 5 | 25 | 228 | 5.0 | 45.6 |
| 6 | Texas | 4 | 17 | 170 | 4.3 | 42.5 |
| 7 | Baylor | 4 | 20 | 163 | 5.0 | 40.8 |
| 8 | West Virginia | 4 | 20 | 159 | 5.0 | 39.8 |
| 9 | Iowa State | 4 | 18 | 157 | 4.5 | 39.3 |
| 10 | Kansas | 4 | 17 | 120 | 4.3 | 30.0 |