2021 Big 12 Conference Leaders Opponent First Downs - Games vs. Unranked Teams Only (AP Poll) through 01/10/2022
| Name | G | Rush | Pass | Penalty | Total | Total/G | |
|---|---|---|---|---|---|---|---|
| 1 | Iowa State | 8 | 60 | 72 | 7 | 139 | 17.4 |
| 2 | Texas | 7 | 60 | 73 | 11 | 144 | 20.6 |
| 3 | Oklahoma State | 10 | 50 | 78 | 19 | 147 | 14.7 |
| 4 | Kansas State | 10 | 64 | 89 | 11 | 164 | 16.4 |
| 5 | Baylor | 9 | 58 | 89 | 20 | 167 | 18.6 |
| 6 | West Virginia | 10 | 80 | 78 | 11 | 169 | 16.9 |
| 7 | Texas Tech | 9 | 68 | 104 | 12 | 184 | 20.4 |
| 8 | TCU | 9 | 87 | 87 | 11 | 185 | 20.6 |
| 9 | Oklahoma | 10 | 67 | 122 | 14 | 203 | 20.3 |
| 10 | Kansas | 9 | 109 | 89 | 11 | 209 | 23.2 |