2021 Big 12 Conference Leaders Passing Defense - Games vs. Unranked Teams Only (AP Poll) through 01/10/2022
| Name | G | Att | Comp | Pct. | Yards | Yards/Att | TD | Int | Rating | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Kansas State | 10 | 280 | 188 | 67.1 | 1980 | 7.1 | 10 | 10 | 131.18 | 28.0 | 198.0 |
| 2 | Iowa State | 8 | 233 | 143 | 61.4 | 1668 | 7.2 | 12 | 9 | 130.78 | 29.1 | 208.5 |
| 3 | Oklahoma State | 10 | 294 | 168 | 57.1 | 1829 | 6.2 | 6 | 8 | 110.70 | 29.4 | 182.9 |
| 3 | TCU | 9 | 240 | 149 | 62.1 | 2133 | 8.9 | 12 | 8 | 146.57 | 26.7 | 237.0 |
| 5 | West Virginia | 10 | 270 | 169 | 62.6 | 1958 | 7.3 | 10 | 7 | 130.54 | 27.0 | 195.8 |
| 5 | Baylor | 9 | 285 | 170 | 59.6 | 2043 | 7.2 | 10 | 7 | 126.53 | 31.7 | 227.0 |
| 5 | Oklahoma | 10 | 354 | 235 | 66.4 | 2766 | 7.8 | 21 | 7 | 147.65 | 35.4 | 276.6 |
| 8 | Kansas | 9 | 238 | 167 | 70.2 | 2147 | 9.0 | 19 | 6 | 167.25 | 26.4 | 238.6 |
| 8 | Texas Tech | 9 | 308 | 206 | 66.9 | 2351 | 7.6 | 17 | 6 | 145.31 | 34.2 | 261.2 |
| 10 | Texas | 7 | 214 | 152 | 71.0 | 1571 | 7.3 | 11 | 2 | 147.78 | 30.6 | 224.4 |