2021 Big 12 Conference Leaders Passing Defense - Games vs. Ranked Teams Only (AP Poll) through 01/10/2022
| Name | G | Att | Comp | Pct. | Yards | Yards/Att | TD | Int | Rating | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | TCU | 3 | 68 | 49 | 72.1 | 744 | 10.9 | 8 | 2 | 196.90 | 22.7 | 248.0 |
| 2 | Iowa State | 5 | 116 | 70 | 60.3 | 767 | 6.6 | 7 | 2 | 132.35 | 23.2 | 153.4 |
| 3 | Kansas | 3 | 76 | 54 | 71.1 | 690 | 9.1 | 8 | 1 | 179.42 | 25.3 | 230.0 |
| 4 | Oklahoma | 3 | 91 | 58 | 63.7 | 637 | 7.0 | 5 | 4 | 131.88 | 30.3 | 212.3 |
| 5 | Baylor | 5 | 159 | 97 | 61.0 | 1149 | 7.2 | 3 | 12 | 112.85 | 31.8 | 229.8 |
| 6 | Kansas State | 3 | 97 | 70 | 72.2 | 818 | 8.4 | 5 | 1 | 157.96 | 32.3 | 272.7 |
| 7 | Texas | 5 | 163 | 103 | 63.2 | 1117 | 6.9 | 5 | 5 | 124.75 | 32.6 | 223.4 |
| 8 | West Virginia | 3 | 98 | 67 | 68.4 | 792 | 8.1 | 7 | 2 | 155.75 | 32.7 | 264.0 |
| 9 | Texas Tech | 4 | 146 | 94 | 64.4 | 1136 | 7.8 | 12 | 4 | 151.38 | 36.5 | 284.0 |
| 10 | Oklahoma State | 4 | 163 | 94 | 57.7 | 1114 | 6.8 | 11 | 1 | 136.12 | 40.8 | 278.5 |