2021 Big 12 Conference Leaders Rushing Defense - From Opponent's 21 To 39 Yard Line through 01/10/2022
| Name | G | Att | Yards | Avg. | TD | Long | 1st | 10+ | 20+ | |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Oklahoma State | 14 | 157 | 411 | 2.62 | 0 | 37 | 23 | 12 | 6 |
| 1 | Oklahoma | 13 | 137 | 637 | 4.65 | 0 | 44 | 34 | 22 | 6 |
| 1 | Kansas | 12 | 123 | 762 | 6.20 | 0 | 66 | 39 | 29 | 4 |
| 4 | West Virginia | 13 | 123 | 577 | 4.69 | 1 | 70 | 22 | 10 | 6 |
| 4 | Texas Tech | 13 | 142 | 603 | 4.25 | 1 | 75 | 32 | 15 | 5 |
| 4 | Iowa State | 13 | 160 | 622 | 3.89 | 1 | 74 | 30 | 19 | 6 |
| 4 | Baylor | 14 | 170 | 658 | 3.87 | 1 | 65 | 35 | 20 | 8 |
| 4 | Kansas State | 13 | 128 | 697 | 5.45 | 1 | 75 | 31 | 19 | 8 |
| 4 | TCU | 12 | 125 | 952 | 7.62 | 1 | 63 | 36 | 28 | 14 |
| 10 | Texas | 12 | 145 | 889 | 6.13 | 2 | 71 | 35 | 20 | 9 |
| 1st: First Downs; 10+: Rush attempts of 10 or more yards; 20+: Rush attempts of 20 or more yards | ||||||||||