2021 Big 12 Conference Leaders Tackles - Games vs. FBS non-Power 5 Conference Teams Only through 01/10/2022
| Name | Team | Yr | Pos | G | Solo | Assisted | Total | Total/G | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Luke Brockermeyer | Texas | JR | LB | 2 | 4 | 12 | 16 | 8.00 |
| 2 | Malcolm Rodriguez | Okla St | SR | LB | 3 | 21 | 11 | 32 | 10.67 |
| 2 | DeMarvion Overshown | Texas | SR | LB | 2 | 6 | 11 | 17 | 8.50 |
| 4 | Devin Harper | Okla St | SR | LB | 3 | 11 | 9 | 20 | 6.67 |
| 4 | Kolby Harvell-Peel | Okla St | SR | S | 3 | 10 | 9 | 19 | 6.33 |
| 4 | Ovie Oghoufo | Texas | JR | EDG | 2 | 3 | 9 | 12 | 6.00 |
| 7 | Terrel Bernard | Baylor | SR | LB | 2 | 7 | 7 | 14 | 7.00 |
| 7 | Dillon Doyle | Baylor | JR | LB | 2 | 6 | 7 | 13 | 6.50 |
| 9 | Brock Martin | Okla St | SR | DE | 3 | 4 | 6 | 10 | 3.33 |
| 9 | Jacoby Jones | Texas | SR | EDG | 2 | 2 | 6 | 8 | 4.00 |
| 9 | Jake Hummel | Iowa State | SR | LB | 1 | 1 | 6 | 7 | 7.00 |
| 12 | Kenny Logan Jr. | Kansas | JR | S | 1 | 3 | 5 | 8 | 8.00 |
| 12 | Mike Rose | Iowa State | SR | LB | 1 | 2 | 5 | 7 | 7.00 |
| 12 | B.J. Foster | Texas | SR | DB | 2 | 2 | 5 | 7 | 3.50 |
| 15 | Jalen Pitre | Baylor | SR | S | 2 | 11 | 4 | 15 | 7.50 |
| 15 | Reggie Pearson Jr. | Texas Tech | JR | DB | 2 | 5 | 4 | 9 | 4.50 |
| 15 | Ricky Thomas Jr. | Kansas | SR | S | 1 | 4 | 4 | 8 | 8.00 |
| 15 | Brandon Bouyer-Randle | Texas Tech | SR | LB | 2 | 4 | 4 | 8 | 4.00 |
| 15 | Gerry Vaughn | Iowa State | JR | LB | 1 | 3 | 4 | 7 | 7.00 |
| 15 | Anthony Cook | Texas | SR | DB | 2 | 2 | 4 | 6 | 3.00 |
| 15 | Nate Betts | Kansas | SR | LB | 1 | 1 | 4 | 5 | 5.00 |
| 15 | Jaylan Ford | Texas | SO | LB | 2 | 1 | 4 | 5 | 2.50 |
| 15 | Greg Eisworth II | Iowa State | SR | DB | 1 | 0 | 4 | 4 | 4.00 |
| 15 | Tre Sterling | Okla St | SR | S | 2 | 0 | 4 | 4 | 2.00 |
| 15 | Brendon Evers | Okla St | SR | DT | 3 | 0 | 4 | 4 | 1.33 |
| 26 | Delarrin Turner-Yell | Oklahoma | SR | S | 1 | 7 | 3 | 10 | 10.00 |
| 26 | Jesiah Pierre | Texas Tech | SO | LB | 2 | 6 | 3 | 9 | 4.50 |
| 26 | D'Shawn Jamison | Texas | SR | DB | 2 | 5 | 3 | 8 | 4.00 |
| 26 | Collin Oliver | Okla St | FR | DE | 3 | 3 | 3 | 6 | 2.00 |
| 26 | Ashton Logan | Baylor | SR | OLB | 2 | 2 | 3 | 5 | 2.50 |
| 26 | Jaylon Hutchings | Texas Tech | JR | DL | 2 | 2 | 3 | 5 | 2.50 |
| 26 | Kym-Mani King | Iowa State | JR | DB | 1 | 1 | 3 | 4 | 4.00 |
| 26 | Eyioma Uwazurike | Iowa State | SR | DE | 1 | 1 | 3 | 4 | 4.00 |
| 26 | Aric Horne | Iowa State | SO | LB | 1 | 1 | 3 | 4 | 4.00 |
| 26 | T'Vondre Sweat | Texas | JR | DL | 2 | 1 | 3 | 4 | 2.00 |
| 26 | Perrion Winfrey | Oklahoma | SR | DL | 1 | 0 | 3 | 3 | 3.00 |
| 26 | Demarco Jones | Okla St | SO | CB | 3 | 0 | 3 | 3 | 1.00 |
| 38 | Colin Schooler | Texas Tech | SR | LB | 2 | 12 | 2 | 14 | 7.00 |
| 38 | Jayden Jernigan | Okla St | SO | DT | 3 | 8 | 2 | 10 | 3.33 |
| 38 | Wyatt Harris | TCU | JR | LB | 1 | 7 | 2 | 9 | 9.00 |
| 38 | Krishon Merriweather | Texas Tech | SR | LB | 2 | 7 | 2 | 9 | 4.50 |
| 38 | Devin Drew | Texas Tech | SR | DL | 2 | 6 | 2 | 8 | 4.00 |
| 38 | Tyler Lacy | Okla St | JR | DE | 3 | 6 | 2 | 8 | 2.67 |
| 38 | Kyron Johnson | Kansas | SR | DE | 1 | 5 | 2 | 7 | 7.00 |
| 38 | JT Woods | Baylor | SR | S | 2 | 5 | 2 | 7 | 3.50 |
| 38 | Riko Jeffers | Texas Tech | SR | LB | 2 | 5 | 2 | 7 | 3.50 |
| 38 | Gavin Potter | Kansas | JR | LB | 1 | 4 | 2 | 6 | 6.00 |
| 38 | D.J. Graham | Oklahoma | SO | CB | 1 | 4 | 2 | 6 | 6.00 |
| 38 | TJ Franklin | Baylor | JR | DL | 2 | 4 | 2 | 6 | 3.00 |
| 38 | Raleigh Texada | Baylor | SR | CB | 2 | 4 | 2 | 6 | 3.00 |