2021 Big 12 Conference Leaders Passes Defended - Games in December/January Only through 01/10/2022
| Name | Team | Yr | Pos | G | Int. | Passes Broken Up | Passes Defended | Passes Defended/G | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Dadrion Taylor-Demerson | Texas Tech | JR | DB | 1 | 0 | 3 | 3 | 3.00 |
| 2 | JT Woods | Baylor | SR | S | 2 | 3 | 1 | 4 | 2.00 |
| 2 | Jake Hummel | Iowa State | SR | LB | 1 | 1 | 1 | 2 | 2.00 |
| 4 | Jairon McVea | Baylor | SR | S | 2 | 1 | 2 | 3 | 1.50 |
| 4 | Malcolm Rodriguez | Okla St | SR | LB | 2 | 1 | 2 | 3 | 1.50 |
| 6 | Matt Jones | Baylor | SO | LB | 2 | 1 | 1 | 2 | 1.00 |
| 6 | Kalon Barnes | Baylor | SR | CB | 2 | 0 | 2 | 2 | 1.00 |
| 6 | Jalen Pitre | Baylor | SR | S | 2 | 0 | 2 | 2 | 1.00 |
| 6 | Jarrick Bernard-Converse | Okla St | SR | CB | 2 | 0 | 2 | 2 | 1.00 |
| 6 | Jabbar Muhammad | Okla St | SO | CB | 2 | 0 | 2 | 2 | 1.00 |
| 6 | Russ Yeast | Kansas St | SR | DB | 1 | 1 | 0 | 1 | 1.00 |
| 6 | Ross Elder | Kansas St | SR | DB | 1 | 1 | 0 | 1 | 1.00 |
| 6 | Justin Broiles | Oklahoma | SR | DB | 1 | 1 | 0 | 1 | 1.00 |
| 6 | Eric Monroe | Texas Tech | SR | DB | 1 | 1 | 0 | 1 | 1.00 |
| 6 | Charles Woods | WVU | JR | CB | 1 | 1 | 0 | 1 | 1.00 |
| 6 | T.J. Tampa | Iowa State | SO | DB | 1 | 0 | 1 | 1 | 1.00 |
| 6 | Craig McDonald | Iowa State | FR | DB | 1 | 0 | 1 | 1 | 1.00 |
| 6 | Will McDonald IV | Iowa State | JR | DE | 1 | 0 | 1 | 1 | 1.00 |
| 6 | Julius Brents | Kansas St | JR | DB | 1 | 0 | 1 | 1 | 1.00 |
| 6 | Ekow Boye-Doe | Kansas St | JR | DB | 1 | 0 | 1 | 1 | 1.00 |
| 6 | Woodi Washington | Oklahoma | SO | CB | 1 | 0 | 1 | 1 | 1.00 |
| 6 | Adrian Frye | Texas Tech | SR | DB | 1 | 0 | 1 | 1 | 1.00 |
| 6 | DaMarcus Fields | Texas Tech | SR | DB | 1 | 0 | 1 | 1 | 1.00 |
| 6 | Tyree Wilson | Texas Tech | JR | DL | 1 | 0 | 1 | 1 | 1.00 |
| 6 | Rayshad Williams | Texas Tech | JR | DB | 1 | 0 | 1 | 1 | 1.00 |
| 6 | Lance Dixon | WVU | SO | LB | 1 | 0 | 1 | 1 | 1.00 |
| 27 | Brayden Utley | Baylor | JR | DL | 2 | 1 | 0 | 1 | 0.50 |
| 27 | Al Walcott | Baylor | JR | CB | 2 | 1 | 0 | 1 | 0.50 |
| 27 | Terrel Bernard | Baylor | SR | LB | 2 | 0 | 1 | 1 | 0.50 |
| 27 | Mark Milton | Baylor | JR | CB | 2 | 0 | 1 | 1 | 0.50 |
| 27 | Raleigh Texada | Baylor | SR | CB | 2 | 0 | 1 | 1 | 0.50 |
| 27 | Tanner McCalister | Okla St | SR | S | 2 | 0 | 1 | 1 | 0.50 |
| 27 | Christian Holmes | Okla St | SR | CB | 2 | 0 | 1 | 1 | 0.50 |
| 27 | Jason Taylor II | Okla St | JR | S | 2 | 0 | 1 | 1 | 0.50 |
| 27 | Kolby Harvell-Peel | Okla St | SR | S | 2 | 0 | 1 | 1 | 0.50 |
| 27 | Jayden Jernigan | Okla St | SO | DT | 2 | 0 | 1 | 1 | 0.50 |
Note: To qualify, player must have played in 75% of his team's games.