2021 Big 12 Conference Leaders Interceptions - Games vs. Ranked Teams Only (AP Poll) through 01/10/2022
| Name | Team | Yr | Pos | G | Int. | Yards | TD | Int./G | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | JT Woods | Baylor | SR | S | 5 | 4 | 49 | 0 | 0.80 |
| 2 | B.J. Foster | Texas | SR | DB | 5 | 3 | 40 | 0 | 0.60 |
| 3 | Woodi Washington | Oklahoma | SO | CB | 3 | 2 | 32 | 0 | 0.67 |
| 3 | Al Walcott | Baylor | JR | CB | 5 | 2 | 96 | 1 | 0.40 |
| 5 | Kee'yon Stewart | TCU | JR | CB | 2 | 1 | 0 | 0 | 0.50 |
| 5 | Justin Broiles | Oklahoma | SR | DB | 3 | 1 | 12 | 0 | 0.33 |
| 5 | Julius Brents | Kansas St | JR | DB | 3 | 1 | 0 | 0 | 0.33 |
| 5 | Ricky Thomas Jr. | Kansas | SR | S | 3 | 1 | 0 | 0 | 0.33 |
| 5 | Delarrin Turner-Yell | Oklahoma | SR | S | 3 | 1 | 0 | 0 | 0.33 |
| 5 | Shadrach Banks | TCU | FR | LB | 3 | 1 | 0 | 0 | 0.33 |
| 5 | Adrian Frye | Texas Tech | SR | DB | 3 | 1 | 0 | 0 | 0.33 |
| 5 | Reggie Pearson Jr. | Texas Tech | JR | DB | 3 | 1 | 0 | 0 | 0.33 |
| 5 | Jackie Matthews | WVU | JR | CB | 3 | 1 | 0 | 0 | 0.33 |
| 5 | Dante Stills | WVU | SR | DL | 3 | 1 | 0 | 0 | 0.33 |
| 5 | Riko Jeffers | Texas Tech | SR | LB | 4 | 1 | 13 | 1 | 0.25 |
| 5 | Malcolm Rodriguez | Okla St | SR | LB | 4 | 1 | 11 | 0 | 0.25 |
| 5 | Kalon Barnes | Baylor | SR | CB | 4 | 1 | 0 | 0 | 0.25 |
| 5 | Eric Monroe | Texas Tech | SR | DB | 4 | 1 | 0 | 0 | 0.25 |
| 5 | Brayden Utley | Baylor | JR | DL | 5 | 1 | 15 | 0 | 0.20 |
| 5 | Luke Brockermeyer | Texas | JR | LB | 5 | 1 | 9 | 0 | 0.20 |
| 5 | Dillon Doyle | Baylor | JR | LB | 5 | 1 | 5 | 0 | 0.20 |
| 5 | Raleigh Texada | Baylor | SR | CB | 5 | 1 | 2 | 0 | 0.20 |
| 5 | Craig McDonald | Iowa State | FR | DB | 5 | 1 | 2 | 0 | 0.20 |
| 5 | Jairon McVea | Baylor | SR | S | 5 | 1 | 0 | 0 | 0.20 |
| 5 | Matt Jones | Baylor | SO | LB | 5 | 1 | 0 | 0 | 0.20 |
| 5 | Jake Hummel | Iowa State | SR | LB | 5 | 1 | 0 | 0 | 0.20 |
| 5 | D'Shawn Jamison | Texas | SR | DB | 5 | 1 | 0 | 0 | 0.20 |