2021 Big 12 Conference Leaders Long Scrimmage Plays - Games vs. Non-Conference Teams Only through 01/10/2022
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| Name | Team | Yr | Pos | G | Yards | Yards | Yards | Yards | Yards | Yards | Yards | Yards | Yards | |
| 1 | Taye Barber | TCU | SR | WR | 3 | 6 | 3 | 2 | 1 | 1 | 1 | 0 | 0 | 0 |
| 1 | Tahj Brooks | Texas Tech | SO | RB | 4 | 9 | 3 | 3 | 3 | 1 | 1 | 0 | 0 | 0 |
| 1 | Leddie Brown | WVU | SR | RB | 3 | 9 | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 0 |
| 1 | Erik Ezukanma | Texas Tech | JR | WR | 3 | 10 | 6 | 6 | 3 | 3 | 1 | 1 | 0 | 0 |
| 1 | Daniel Imatorbhebhe | Kansas St | SR | TE | 4 | 4 | 3 | 1 | 1 | 1 | 1 | 0 | 0 | 0 |
| 1 | Roschon Johnson | Texas | JR | RB | 3 | 4 | 2 | 1 | 1 | 1 | 1 | 1 | 0 | 0 |
| 1 | Kwamie Lassiter II | Kansas | SR | WR | 3 | 7 | 3 | 1 | 1 | 1 | 1 | 0 | 0 | 0 |
| 1 | Devin Neal | Kansas | FR | RB | 3 | 3 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 |
| 1 | Bijan Robinson | Texas | SO | RB | 3 | 10 | 3 | 1 | 1 | 1 | 1 | 0 | 0 | 0 |
| 1 | Keilan Robinson | Texas | JR | RB | 3 | 3 | 2 | 1 | 1 | 1 | 1 | 0 | 0 | 0 |
| 1 | Jaylen Warren | Okla St | SR | RB | 4 | 13 | 4 | 1 | 1 | 1 | 1 | 1 | 0 | 0 |