2021 Big 12 Conference Leaders Rushing - From Own 40 to Opponent's 40 Yard Line through 01/10/2022
| Name | Team | Yr | Pos | G | Att | Yards | Avg. | TD | Long | 1st | 10+ | 20+ | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Deuce Vaughn | Kansas St | SO | RB | 13 | 58 | 383 | 6.60 | 2 | 59 | 17 | 13 | 4 |
| 2 | Kendre Miller | TCU | SO | RB | 9 | 18 | 166 | 9.22 | 2 | 56 | 6 | 3 | 2 |
| 3 | Abram Smith | Baylor | SR | RB | 14 | 66 | 431 | 6.53 | 1 | 55 | 23 | 14 | 6 |
| 4 | Breece Hall | Iowa State | JR | RB | 12 | 66 | 411 | 6.23 | 1 | 53 | 20 | 10 | 7 |
| 5 | Xavier White | Texas Tech | JR | RB | 11 | 18 | 97 | 5.39 | 0 | 52 | 4 | 1 | 1 |
| 6 | Zach Evans | TCU | SO | RB | 6 | 26 | 265 | 10.19 | 1 | 51 | 10 | 6 | 4 |
| 7 | Bijan Robinson | Texas | SO | RB | 10 | 46 | 355 | 7.72 | 0 | 50 | 16 | 11 | 3 |
| 8 | Keilan Robinson | Texas | JR | RB | 7 | 14 | 171 | 12.21 | 1 | 49 | 6 | 5 | 4 |
| 9 | Eric Gray | Oklahoma | JR | RB | 11 | 20 | 156 | 7.80 | 0 | 48 | 6 | 5 | 1 |
| 9 | Monaray Baldwin | Baylor | FR | WR | 3 | 3 | 51 | 17.00 | 1 | 48 | 1 | 1 | 1 |
| 11 | Jason Bean | Kansas | JR | QB | 7 | 17 | 124 | 7.29 | 1 | 46 | 6 | 4 | 2 |
| 12 | Erik Ezukanma | Texas Tech | JR | WR | 4 | 4 | 68 | 17.00 | 1 | 45 | 2 | 2 | 2 |
| 13 | Leddie Brown | WVU | SR | RB | 11 | 63 | 300 | 4.76 | 1 | 44 | 15 | 6 | 4 |
| 13 | Tahj Brooks | Texas Tech | SO | RB | 8 | 26 | 187 | 7.19 | 2 | 44 | 10 | 5 | 2 |
| 15 | Jaylen Warren | Okla St | SR | RB | 13 | 60 | 322 | 5.37 | 0 | 43 | 17 | 10 | 4 |
| 15 | Derius Davis | TCU | SR | WR | 3 | 4 | 62 | 15.50 | 1 | 43 | 2 | 3 | 1 |
| 17 | Max Duggan | TCU | JR | QB | 7 | 24 | 54 | 2.25 | 0 | 42 | 6 | 5 | 2 |
| 18 | Caleb Williams | Oklahoma | FR | QB | 6 | 17 | 126 | 7.41 | 2 | 41 | 7 | 4 | 3 |
| 18 | Hunter Dekkers | Iowa State | FR | QB | 2 | 2 | 53 | 26.50 | 1 | 41 | 2 | 2 | 1 |
| 20 | Kennedy Brooks | Oklahoma | JR | RB | 13 | 53 | 281 | 5.30 | 0 | 40 | 12 | 6 | 3 |
| 20 | Jirehl Brock | Iowa State | SO | RB | 8 | 9 | 89 | 9.89 | 1 | 40 | 3 | 2 | 1 |
| 22 | Spencer Sanders | Okla St | JR | QB | 10 | 33 | 139 | 4.21 | 0 | 37 | 13 | 7 | 1 |
| 23 | Trestan Ebner | Baylor | SR | RB | 13 | 45 | 251 | 5.58 | 0 | 30 | 11 | 9 | 1 |
| 24 | Andrew Mevis | Iowa State | SR | PK | 1 | 1 | 29 | 29.00 | 0 | 29 | 1 | 1 | 1 |
| 25 | Blake Shapen | Baylor | FR | QB | 2 | 4 | 53 | 13.25 | 0 | 28 | 3 | 2 | 1 |
| 26 | Roschon Johnson | Texas | JR | RB | 9 | 23 | 158 | 6.87 | 0 | 27 | 9 | 4 | 1 |
| 27 | Chandler Morris | TCU | FR | QB | 3 | 4 | 31 | 7.75 | 0 | 26 | 2 | 1 | 1 |
| 28 | Garrett Greene | WVU | FR | QB | 6 | 10 | 89 | 8.90 | 0 | 25 | 5 | 4 | 1 |
| 28 | Henry Colombi | Texas Tech | SR | QB | 4 | 9 | 20 | 2.22 | 0 | 25 | 1 | 1 | 1 |
| 30 | SaRodorick Thompson | Texas Tech | JR | RB | 8 | 16 | 85 | 5.31 | 0 | 24 | 8 | 3 | 2 |
| 31 | Brock Purdy | Iowa State | SR | QB | 11 | 22 | 34 | 1.55 | 0 | 22 | 5 | 2 | 1 |
| 32 | Devin Neal | Kansas | FR | RB | 9 | 33 | 136 | 4.12 | 0 | 21 | 9 | 4 | 1 |
| 33 | Will Howard | Kansas St | SO | QB | 3 | 4 | 25 | 6.25 | 0 | 19 | 1 | 1 | 0 |
| 34 | Deon Silas | Iowa State | FR | RB | 3 | 3 | 34 | 11.33 | 0 | 18 | 2 | 2 | 0 |
| 34 | Skylar Thompson | Kansas St | SR | QB | 8 | 13 | -44 | -3.38 | 0 | 18 | 2 | 2 | 0 |
| 36 | Emari Demercado | TCU | SR | RB | 8 | 23 | 78 | 3.39 | 0 | 17 | 4 | 2 | 0 |
| 36 | Jalon Daniels | Kansas | SO | QB | 5 | 9 | 45 | 5.00 | 0 | 17 | 4 | 1 | 0 |
| 38 | Dominic Richardson | Okla St | SO | RB | 9 | 15 | 82 | 5.47 | 0 | 16 | 5 | 2 | 0 |
| 39 | Joe Ervin | Kansas St | SO | RB | 8 | 21 | 90 | 4.29 | 0 | 15 | 7 | 3 | 0 |
| 39 | Myles Price | Texas Tech | SO | WR | 6 | 9 | 40 | 4.44 | 0 | 15 | 4 | 2 | 0 |
| 41 | Tony Mathis Jr. | WVU | SO | RB | 7 | 13 | 69 | 5.31 | 0 | 14 | 5 | 2 | 0 |
| 41 | Jonathon Brooks | Texas | FR | RB | 3 | 8 | 50 | 6.25 | 0 | 14 | 3 | 1 | 0 |
| 41 | Trevor Wilson | Kansas | SO | WR | 3 | 3 | 19 | 6.33 | 0 | 14 | 1 | 1 | 0 |
| 41 | Tyler Shough | Texas Tech | JR | QB | 3 | 5 | 7 | 1.40 | 0 | 14 | 2 | 1 | 0 |
| 45 | Malik Knowles | Kansas St | JR | WR | 4 | 5 | 25 | 5.00 | 0 | 13 | 2 | 2 | 0 |
| 45 | Hudson Card | Texas | FR | QB | 4 | 8 | 7 | 0.88 | 0 | 13 | 2 | 1 | 0 |
| 47 | Amauri Pesek-Hickson | Kansas | FR | RB | 6 | 14 | 45 | 3.21 | 0 | 12 | 2 | 1 | 0 |
| 47 | Casey Thompson | Texas | JR | QB | 9 | 15 | 30 | 2.00 | 0 | 12 | 6 | 1 | 0 |
| 47 | Trevon West | Oklahoma | SO | WR | 1 | 1 | 12 | 12.00 | 0 | 12 | 1 | 1 | 0 |
| 47 | Jarret Doege | WVU | SR | QB | 10 | 23 | -53 | -2.30 | 0 | 12 | 6 | 2 | 0 |
| 1st: First Downs; 10+: Rush attempts of 10 or more yards; 20+: Rush attempts of 20 or more yards | |||||||||||||