2021 Conference USA Leaders Tackles For Loss - Games vs. FBS Power 5 Conference Teams Only through 01/10/2022
| Name | G | TFL | TFL Yards | TFL/G | |
|---|---|---|---|---|---|
| 1 | Western Kentucky | 2 | 12.0 | 49 | 6.00 |
| 2 | Louisiana Tech | 2 | 8.0 | 41 | 4.00 |
| 3 | Charlotte | 2 | 10.0 | 36 | 5.00 |
| 4 | North Texas | 1 | 11.0 | 34 | 11.00 |
| 5 | Old Dominion | 1 | 6.0 | 18 | 6.00 |
| 6 | Middle Tennessee | 1 | 5.0 | 17 | 5.00 |
| 6 | Southern Mississippi | 1 | 4.0 | 17 | 4.00 |
| 8 | Rice | 2 | 4.0 | 16 | 2.00 |
| 9 | UTSA | 1 | 6.0 | 12 | 6.00 |
| 10 | Florida Atlantic | 1 | 4.0 | 7 | 4.00 |
| 10 | UAB | 1 | 2.0 | 7 | 2.00 |
| 12 | Florida International | 1 | 1.0 | 5 | 1.00 |