2021 Conference USA Leaders Passing Offense - Games vs. FBS Power 5 Conference Teams Only through 01/10/2022
| Name | G | Att | Comp | Pct. | Yards | Yards/Att | TD | Int | Rating | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | North Texas | 1 | 26 | 16 | 61.5 | 305 | 11.7 | 4 | 2 | 195.47 | 26.0 | 305.0 |
| 2 | Charlotte | 2 | 53 | 36 | 67.9 | 515 | 9.7 | 5 | 1 | 176.91 | 26.5 | 257.5 |
| 3 | UTSA | 1 | 32 | 20 | 62.5 | 280 | 8.8 | 1 | 0 | 146.31 | 32.0 | 280.0 |
| 4 | Florida Atlantic | 1 | 33 | 19 | 57.6 | 261 | 7.9 | 1 | 0 | 134.02 | 33.0 | 261.0 |
| 5 | Western Kentucky | 2 | 109 | 77 | 70.6 | 853 | 7.8 | 6 | 0 | 154.55 | 54.5 | 426.5 |
| 6 | Louisiana Tech | 2 | 81 | 47 | 58.0 | 609 | 7.5 | 5 | 3 | 134.15 | 40.5 | 304.5 |
| 7 | Middle Tennessee | 1 | 40 | 26 | 65.0 | 283 | 7.1 | 2 | 1 | 135.93 | 40.0 | 283.0 |
| 8 | Florida International | 1 | 29 | 13 | 44.8 | 191 | 6.6 | 2 | 1 | 116.01 | 29.0 | 191.0 |
| 9 | Rice | 2 | 59 | 36 | 61.0 | 355 | 6.0 | 1 | 3 | 106.98 | 29.5 | 177.5 |
| 10 | Southern Mississippi | 1 | 24 | 11 | 45.8 | 131 | 5.5 | 2 | 1 | 110.85 | 24.0 | 131.0 |
| 11 | Old Dominion | 1 | 38 | 18 | 47.4 | 127 | 3.3 | 1 | 2 | 73.60 | 38.0 | 127.0 |
| 12 | UAB | 1 | 17 | 8 | 47.1 | 47 | 2.8 | 0 | 3 | 35.00 | 17.0 | 47.0 |