2021 Conference USA Leaders Tackles For Loss - Games vs. Unranked Teams Only (AP Poll) through 01/10/2022
| Name | G | TFL | TFL Yards | TFL/G | |
|---|---|---|---|---|---|
| 1 | Middle Tennessee State | 13 | 88.0 | 367 | 6.77 |
| 2 | North Texas | 13 | 87.0 | 390 | 6.69 |
| 3 | UTSA | 13 | 84.0 | 372 | 6.46 |
| 4 | Marshall | 12 | 80.0 | 338 | 6.67 |
| 5 | Western Kentucky | 13 | 77.0 | 333 | 5.92 |
| 5 | UTEP | 13 | 77.0 | 300 | 5.92 |
| 7 | UAB | 11 | 71.0 | 313 | 6.46 |
| 8 | Florida Atlantic | 12 | 68.0 | 259 | 5.67 |
| 9 | Old Dominion | 12 | 64.0 | 261 | 5.33 |
| 10 | Southern Miss | 11 | 63.0 | 256 | 5.73 |
| 11 | Louisiana Tech | 11 | 61.0 | 245 | 5.55 |
| 12 | FIU | 12 | 55.0 | 159 | 4.58 |
| 13 | Charlotte | 12 | 54.0 | 223 | 4.50 |
| 14 | Rice | 10 | 51.0 | 221 | 5.10 |