2021 Conference USA Leaders Opponent First Downs - Games in December/January Only through 01/10/2022
| Name | G | Rush | Pass | Penalty | Total | Total/G | |
|---|---|---|---|---|---|---|---|
| 1 | UAB | 1 | 9 | 6 | 2 | 17 | 17.0 |
| 2 | Middle Tennessee | 1 | 13 | 7 | 1 | 21 | 21.0 |
| 3 | Marshall | 1 | 10 | 11 | 2 | 23 | 23.0 |
| 4 | North Texas | 1 | 11 | 12 | 4 | 27 | 27.0 |
| 5 | UTEP | 1 | 10 | 15 | 1 | 26 | 26.0 |
| 5 | Old Dominion | 1 | 17 | 15 | 3 | 35 | 35.0 |
| 7 | Western Kentucky | 2 | 27 | 24 | 1 | 52 | 26.0 |
| 8 | UTSA | 2 | 13 | 39 | 5 | 57 | 28.5 |