2021 Conference USA Leaders Opponent First Downs - Games vs. Ranked Teams Only (AP Poll) through 01/10/2022
| Name | G | Rush | Pass | Penalty | Total | Total/G | |
|---|---|---|---|---|---|---|---|
| 1 | Old Dominion | 1 | 7 | 10 | 3 | 20 | 20.0 |
| 2 | Southern Mississippi | 1 | 8 | 13 | 1 | 22 | 22.0 |
| 3 | Louisiana Tech | 1 | 9 | 12 | 2 | 23 | 23.0 |
| 3 | Marshall | 1 | 10 | 11 | 2 | 23 | 23.0 |
| 5 | Western Kentucky | 1 | 10 | 13 | 3 | 26 | 26.0 |
| 6 | UTSA | 1 | 10 | 17 | 4 | 31 | 31.0 |
| 7 | UAB | 2 | 20 | 16 | 4 | 40 | 20.0 |
| 8 | Rice | 2 | 21 | 16 | 4 | 41 | 20.5 |