2021 Conference USA Leaders Scoring Defense - Games vs. Ranked Teams Only (AP Poll) through 01/10/2022
| Name | G | TD | FG | 1XP | 2XP | Safety | Points | Points/G | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Louisiana Tech | 1 | 4 | 2 | 4 | 0 | 0 | 34 | 34.0 |
| 1 | Marshall | 1 | 4 | 3 | 3 | 0 | 0 | 36 | 36.0 |
| 1 | UTSA | 1 | 5 | 1 | 5 | 0 | 0 | 38 | 38.0 |
| 1 | Rice | 2 | 11 | 2 | 10 | 0 | 0 | 82 | 41.0 |
| 1 | Old Dominion | 1 | 6 | 0 | 6 | 0 | 0 | 42 | 42.0 |
| 1 | UAB | 2 | 12 | 0 | 12 | 0 | 0 | 84 | 42.0 |
| 1 | Western Kentucky | 1 | 6 | 2 | 6 | 0 | 0 | 48 | 48.0 |
| 1 | Southern Mississippi | 1 | 9 | 0 | 9 | 0 | 0 | 63 | 63.0 |