2021 Conference USA Leaders Passing Defense - Games vs. Ranked Teams Only (AP Poll) through 01/10/2022
| Name | G | Att | Comp | Pct. | Yards | Yards/Att | TD | Int | Rating | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Marshall | 1 | 32 | 20 | 62.5 | 278 | 8.7 | 1 | 0 | 145.79 | 32.0 | 278.0 |
| 1 | Western Kentucky | 1 | 30 | 20 | 66.7 | 327 | 10.9 | 1 | 0 | 169.23 | 30.0 | 327.0 |
| 3 | Louisiana Tech | 1 | 36 | 22 | 61.1 | 251 | 7.0 | 2 | 0 | 138.00 | 36.0 | 251.0 |
| 4 | Old Dominion | 1 | 29 | 18 | 62.1 | 188 | 6.5 | 3 | 0 | 150.67 | 29.0 | 188.0 |
| 4 | Rice | 2 | 54 | 35 | 64.8 | 377 | 7.0 | 3 | 1 | 138.09 | 27.0 | 188.5 |
| 4 | UTSA | 1 | 36 | 24 | 66.7 | 333 | 9.3 | 3 | 0 | 171.87 | 36.0 | 333.0 |
| 7 | UAB | 2 | 45 | 29 | 64.4 | 571 | 12.7 | 6 | 1 | 210.59 | 22.5 | 285.5 |
| 7 | Southern Mississippi | 1 | 26 | 23 | 88.5 | 395 | 15.2 | 6 | 1 | 284.53 | 26.0 | 395.0 |