2021 Conference USA Leaders Passing Defense - When Winning By 15+ Pts through 01/10/2022
| Name | G | Att | Comp | Pct. | Yards | TD | Int | Rating | Long | 1st | 15+ | 25+ | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Middle Tennessee | 5 | 71 | 37 | 52.1 | 305 | 0 | 6 | 71.30 | 35 | 16 | 6 | 2 |
| 2 | Louisiana Tech | 3 | 37 | 22 | 59.5 | 277 | 2 | 0 | 140.18 | 38 | 13 | 9 | 3 |
| 3 | UTEP | 6 | 54 | 24 | 44.4 | 294 | 2 | 3 | 91.28 | 41 | 13 | 9 | 3 |
| 4 | UAB | 7 | 91 | 44 | 48.4 | 370 | 2 | 2 | 85.35 | 44 | 14 | 7 | 3 |
| 5 | Florida Atlantic | 5 | 68 | 36 | 52.9 | 443 | 1 | 6 | 94.87 | 48 | 22 | 7 | 5 |
| 6 | UTSA | 6 | 113 | 65 | 57.5 | 873 | 8 | 4 | 138.70 | 50 | 34 | 19 | 8 |
| 7 | Marshall | 7 | 133 | 73 | 54.9 | 706 | 3 | 4 | 100.90 | 55 | 30 | 13 | 2 |
| 8 | Western Kentucky | 9 | 191 | 109 | 57.1 | 1347 | 5 | 12 | 112.38 | 62 | 60 | 31 | 10 |
| 9 | Old Dominion | 3 | 34 | 22 | 64.7 | 312 | 4 | 0 | 180.61 | 65 | 14 | 7 | 3 |
| 10 | North Texas | 4 | 48 | 22 | 45.8 | 273 | 2 | 1 | 103.19 | 67 | 9 | 5 | 2 |
| 11 | Rice | 1 | 23 | 15 | 65.2 | 308 | 1 | 0 | 192.05 | 68 | 11 | 7 | 4 |
| 12 | Florida International | 2 | 32 | 17 | 53.1 | 250 | 2 | 0 | 139.39 | 74 | 10 | 5 | 3 |
| 13 | Charlotte | 2 | 32 | 16 | 50.0 | 364 | 4 | 0 | 186.80 | 75 | 12 | 9 | 3 |
| 14 | Southern Mississippi | 3 | 22 | 11 | 50.0 | 199 | 1 | 3 | 113.71 | 91 | 6 | 5 | 2 |
| 1st: First Downs; 15+: Pass completions of 15 or more yards; 25+: Pass completions of 25 or more yards | |||||||||||||