2021 Conference USA Leaders Total Offense - Games in August/September Only through 01/10/2022
| Name | Team | Yr | Pos | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Bailey Zappe | Western Ky | SR | QB | 3 | 37 | 1224 | 130 | 1261 | 9.70 | 420.3 |
| 2 | Gavin Hardison | UTEP | SO | QB | 4 | -29 | 948 | 101 | 919 | 9.10 | 229.8 |
| 3 | Dylan Hopkins | UAB | JR | QB | 4 | 5 | 501 | 60 | 506 | 8.43 | 126.5 |
| 4 | Grant Wells | Marshall | FR | QB | 4 | 37 | 1383 | 169 | 1420 | 8.40 | 355.0 |
| 5 | Chase Cunningham | MTSU | JR | QB | 4 | 71 | 638 | 86 | 709 | 8.24 | 177.3 |
| 6 | Max Bortenschlager | FIU | SR | QB | 4 | -55 | 1105 | 129 | 1050 | 8.14 | 262.5 |
| 7 | Tyler Johnston III | UAB | SR | QB | 3 | 6 | 390 | 50 | 396 | 7.92 | 132.0 |
| 8 | Austin Kendall | La Tech | SR | QB | 3 | 98 | 837 | 120 | 935 | 7.79 | 311.7 |
| 9 | Chris Reynolds | Charlotte | SR | QB | 4 | 143 | 924 | 142 | 1067 | 7.51 | 266.8 |
| 10 | Frank Harris | UTSA | SR | QB | 4 | 91 | 848 | 140 | 939 | 6.71 | 234.8 |
| 11 | Elijah Davis | ODU | SO | RB | 4 | 255 | 0 | 40 | 255 | 6.38 | 63.8 |
| 12 | Calvin Camp | Charlotte | SR | RB | 4 | 258 | 0 | 41 | 258 | 6.29 | 64.5 |
| 13 | D'vonte Price | FIU | SR | RB | 4 | 377 | 0 | 60 | 377 | 6.28 | 94.3 |
| 14 | N'Kosi Perry | FAU | SR | QB | 4 | 51 | 949 | 167 | 1000 | 5.99 | 250.0 |
| 15 | Rasheen Ali | Marshall | FR | RB | 4 | 376 | 0 | 63 | 376 | 5.97 | 94.0 |
| 16 | Johnny Ford | FAU | SO | RB | 3 | 189 | 0 | 33 | 189 | 5.73 | 63.0 |
| 17 | DeAndre Torrey | N Texas | SR | RB | 4 | 516 | 0 | 91 | 516 | 5.67 | 129.0 |
| 18 | DeWayne McBride | UAB | SO | RB | 4 | 282 | 0 | 52 | 282 | 5.42 | 70.5 |
| 19 | Bailey Hockman | MTSU | JR | QB | 3 | -62 | 463 | 75 | 401 | 5.35 | 133.7 |
| 20 | Jordan Myers | Rice | SR | TE | 4 | 224 | 0 | 43 | 224 | 5.21 | 56.0 |
| 21 | Jace Ruder | N Texas | SO | QB | 4 | 48 | 544 | 116 | 592 | 5.10 | 148.0 |
| 22 | Ronald Awatt | UTEP | JR | RB | 4 | 288 | 0 | 57 | 288 | 5.05 | 72.0 |
| 23 | Khalan Griffin | Rice | FR | RB | 4 | 216 | 0 | 44 | 216 | 4.91 | 54.0 |
| 24 | Luke McCaffrey | Rice | FR | QB | 4 | 64 | 181 | 51 | 245 | 4.80 | 61.3 |
| 25 | Jermaine Brown Jr. | UAB | JR | RB | 4 | 221 | 0 | 50 | 221 | 4.42 | 55.3 |
| 26 | Sincere McCormick | UTSA | JR | RB | 4 | 452 | 0 | 103 | 452 | 4.39 | 113.0 |
| 26 | Frank Gore, Jr. | USM | FR | RB | 4 | 281 | 0 | 64 | 281 | 4.39 | 70.3 |
| 28 | Marcus Williams Jr. | La Tech | SR | RB | 4 | 258 | 0 | 60 | 258 | 4.30 | 64.5 |
| 29 | D.J. Mack Jr. | ODU | JR | QB | 4 | 130 | 556 | 160 | 686 | 4.29 | 171.5 |
| 30 | Shadrick Byrd | Charlotte | SO | RB | 4 | 201 | 0 | 50 | 201 | 4.02 | 50.3 |
| 31 | Brenden Brady | UTSA | SR | RB | 4 | 133 | 8 | 36 | 141 | 3.92 | 35.3 |
| 32 | Ty Keyes | USM | FR | QB | 3 | 52 | 338 | 101 | 390 | 3.86 | 130.0 |
| 33 | Austin Aune | N Texas | SO | QB | 4 | 60 | 213 | 73 | 273 | 3.74 | 68.3 |
Note: To qualify, player must have played in 75% of his team's games and have a minimum of 9.0 plays per game played.