2021 Conference USA Leaders Passing - Games vs. Ranked Teams Only (AP Poll) through 01/10/2022
| Name | Team | Yr | Pos | G | Att | Comp | Pct. | Yards | Yards/Att | TD | Int | Rating | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Bailey Zappe | Western Ky | SR | QB | 1 | 64 | 46 | 71.9 | 488 | 7.6 | 3 | 0 | 151.40 | 64.0 | 488.0 |
| 2 | Austin Kendall | La Tech | SR | QB | 1 | 43 | 26 | 60.5 | 341 | 7.9 | 3 | 2 | 140.80 | 43.0 | 341.0 |
| 3 | Frank Harris | UTSA | SR | QB | 1 | 36 | 22 | 61.1 | 255 | 7.1 | 2 | 1 | 133.38 | 36.0 | 255.0 |
| 4 | Dylan Hopkins | UAB | JR | QB | 2 | 26 | 21 | 80.8 | 197 | 7.6 | 3 | 1 | 174.81 | 13.0 | 98.5 |
| 5 | Luke McCaffrey | Rice | FR | QB | 2 | 29 | 14 | 48.3 | 161 | 5.6 | 1 | 3 | 85.61 | 14.5 | 80.5 |
| 6 | Wiley Green | Rice | SO | QB | 1 | 25 | 12 | 48.0 | 152 | 6.1 | 1 | 3 | 88.27 | 25.0 | 152.0 |
| 7 | Ty Keyes | USM | FR | QB | 1 | 24 | 11 | 45.8 | 131 | 5.5 | 2 | 1 | 110.85 | 24.0 | 131.0 |
| 8 | Grant Wells | Marshall | FR | QB | 1 | 26 | 15 | 57.7 | 99 | 3.8 | 0 | 1 | 81.99 | 26.0 | 99.0 |
| 9 | Hayden Wolff | ODU | FR | QB | 1 | 17 | 11 | 64.7 | 88 | 5.2 | 1 | 0 | 127.60 | 17.0 | 88.0 |
| 10 | D.J. Mack Jr. | ODU | JR | QB | 1 | 21 | 7 | 33.3 | 39 | 1.9 | 0 | 2 | 29.88 | 21.0 | 39.0 |
| 10 | Tyler Johnston III | UAB | SR | QB | 1 | 14 | 6 | 42.9 | 39 | 2.8 | 0 | 3 | 23.40 | 14.0 | 39.0 |