2021 Conference USA Leaders Interceptions - Games vs. Non-Conference Teams Only through 01/10/2022
| Name | Team | Yr | Pos | G | Int. | Yards | TD | Int./G | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | BeeJay Williamson | La Tech | SO | DB | 4 | 2 | 62 | 1 | 0.50 |
| 2 | Keondre Swoopes | UAB | JR | S | 5 | 1 | 61 | 1 | 0.20 |
| 3 | Teldrick Ross | MTSU | SO | S | 5 | 1 | 44 | 1 | 0.20 |
| 4 | Trey Baldwin | La Tech | SR | LB | 4 | 1 | 35 | 1 | 0.25 |
| 4 | Micah Abraham | Marshall | SO | DB | 5 | 1 | 35 | 0 | 0.20 |
| 6 | Miguel Edwards | Western Ky | SO | DB | 5 | 2 | 33 | 0 | 0.40 |
| 6 | Decorian Patterson | MTSU | SO | CB | 5 | 1 | 33 | 0 | 0.20 |
| 8 | Dennis Barnes | UTEP | JR | DB | 5 | 1 | 27 | 0 | 0.20 |
| 9 | Quincy Riley | MTSU | FR | CB | 2 | 1 | 26 | 0 | 0.50 |
| 10 | Teja Young | FAU | SO | S | 4 | 2 | 22 | 1 | 0.50 |
| 11 | Damon Miller | UAB | JR | S | 5 | 1 | 21 | 0 | 0.20 |
| 12 | Keylin Roach | Marshall | JR | DB | 4 | 1 | 20 | 0 | 0.25 |
| 13 | Dion Novil | N Texas | SR | DL | 5 | 1 | 17 | 0 | 0.20 |
| 14 | Steven Gilmore | Marshall | JR | DB | 5 | 1 | 15 | 0 | 0.20 |
| 15 | Malik Shorts | USM | SO | DB | 4 | 1 | 13 | 0 | 0.25 |
| 16 | Jahmal Sam | UTSA | SO | S | 2 | 1 | 6 | 0 | 0.50 |
| 17 | George Nyakwol | Rice | SR | DB | 4 | 1 | 5 | 0 | 0.25 |
| 18 | Gregory Grate | MTSU | JR | S | 5 | 2 | 3 | 0 | 0.40 |
| 18 | Zyon Gilbert | FAU | SR | CB | 4 | 1 | 3 | 0 | 0.25 |