2020 Big 12 Conference Leaders Sacks - Games vs. FBS non-Power 5 Conference Teams Only through 01/11/2021
| Name | Team | Yr | Pos | G | Sacks | Sack Yards | Sacks/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Ochaun Mathis | TCU | SO | DE | 1 | 2.0 | 19 | 2.00 |
| 1 | Will McDonald IV | Iowa State | SO | DE | 1 | 2.0 | 11 | 2.00 |
| 3 | Eli Huggins | Kansas St | JR | DT | 1 | 1.0 | 10 | 1.00 |
| 3 | Marcus Tillman, Jr. | Texas | FR | LB | 1 | 1.0 | 10 | 1.00 |
| 3 | Malcolm Rodriguez | Okla St | SR | LB | 1 | 1.0 | 9 | 1.00 |
| 3 | Dylan Horton | TCU | JR | DE | 1 | 1.0 | 7 | 1.00 |
| 3 | Drew Wiley | Kansas St | SR | DT | 1 | 1.0 | 6 | 1.00 |
| 3 | La'Kendrick Van Zandt | TCU | JR | S | 1 | 1.0 | 6 | 1.00 |
| 3 | Garret Wallow | TCU | SR | LB | 1 | 1.0 | 6 | 1.00 |
| 3 | Alfred Collins | Texas | FR | DL | 1 | 1.0 | 6 | 1.00 |
| 3 | Latrell Bankston | Iowa State | JR | DL | 1 | 1.0 | 4 | 1.00 |
| 3 | Wyatt Hubert | Kansas St | JR | DE | 1 | 1.0 | 4 | 1.00 |
Note: To qualify, player must have played in 75% of his team's games.