2022 Atlantic Coast Conference Leaders Total Defense - Games vs. FBS (I-A) Teams Only through 01/09/2023
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Pittsburgh | 12 | 1211 | 2792 | 782 | 4003 | 5.12 | 333.6 |
| 2 | North Carolina State | 12 | 1273 | 2827 | 789 | 4100 | 5.20 | 341.7 |
| 3 | Clemson | 13 | 1313 | 2985 | 856 | 4298 | 5.02 | 330.6 |
| 4 | Duke | 12 | 1355 | 3208 | 828 | 4563 | 5.51 | 380.3 |
| 5 | Virginia | 9 | 1362 | 1884 | 650 | 3246 | 4.99 | 360.7 |
| 6 | Virginia Tech | 10 | 1449 | 2435 | 711 | 3884 | 5.46 | 388.4 |
| 7 | Miami (Florida) | 11 | 1612 | 2548 | 705 | 4160 | 5.90 | 378.2 |
| 8 | Wake Forest | 12 | 1681 | 3350 | 862 | 5031 | 5.84 | 419.3 |
| 9 | Louisville | 13 | 1742 | 2561 | 848 | 4303 | 5.07 | 331.0 |
| 10 | Syracuse | 12 | 1847 | 2384 | 834 | 4231 | 5.07 | 352.6 |
| 11 | Boston College | 11 | 1920 | 2245 | 734 | 4165 | 5.67 | 378.6 |
| 12 | Florida State | 12 | 1940 | 2079 | 816 | 4019 | 4.93 | 334.9 |
| 13 | Georgia Tech | 11 | 2151 | 2278 | 791 | 4429 | 5.60 | 402.6 |
| 14 | North Carolina | 13 | 2257 | 3519 | 929 | 5776 | 6.22 | 444.3 |