2021 Notre Dame Fighting Irish Total Defense Split Stats through 01/10/2022
| Split | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G |
|---|---|---|---|---|---|---|---|
| All Games | 13 | 1761 | 2915 | 887 | 4676 | 5.27 | 359.7 |
| at Home | 7 | 921 | 1571 | 467 | 2492 | 5.34 | 356.0 |
| on Road/Neutral Site | 6 | 840 | 1344 | 420 | 2184 | 5.20 | 364.0 |
| in Wins | 11 | 1434 | 2247 | 730 | 3681 | 5.04 | 334.6 |
| in Losses | 2 | 327 | 668 | 157 | 995 | 6.34 | 497.5 |
| vs. Conference | 0 | 0 | 0 | 0 | 0 | - | - |
| vs. Non-Conference | 13 | 1761 | 2915 | 887 | 4676 | 5.27 | 359.7 |
| vs. Ranked (AP) | 2 | 327 | 668 | 157 | 995 | 6.34 | 497.5 |
| vs. Unranked (AP) | 11 | 1434 | 2247 | 730 | 3681 | 5.04 | 334.6 |
| vs. FBS (I-A) | 13 | 1761 | 2915 | 887 | 4676 | 5.27 | 359.7 |
| vs. FCS (I-AA) | 0 | 0 | 0 | 0 | 0 | - | - |
| vs. FBS Winning | 5 | 586 | 1428 | 368 | 2014 | 5.47 | 402.8 |
| vs. FBS Non-Winning | 8 | 1175 | 1487 | 519 | 2662 | 5.13 | 332.8 |
| vs. FBS Power 5 | 10 | 1378 | 2371 | 704 | 3749 | 5.33 | 374.9 |
| vs. FBS non-Power 5 | 3 | 383 | 544 | 183 | 927 | 5.07 | 309.0 |
| in August/September | 4 | 523 | 938 | 285 | 1461 | 5.13 | 365.3 |
| in October | 4 | 573 | 1124 | 275 | 1697 | 6.17 | 424.3 |
| in November | 4 | 431 | 482 | 232 | 913 | 3.94 | 228.3 |
| in December/January | 1 | 234 | 371 | 95 | 605 | 6.37 | 605.0 |