2021 Iowa State Cyclones Opponent Penalty Split Stats through 01/10/2022
| Split | G | Pen. | Yards | Pen./G | Yards/G |
|---|---|---|---|---|---|
| All Games | 13 | 68 | 622 | 5.2 | 47.8 |
| at Home | 6 | 30 | 253 | 5.0 | 42.2 |
| on Road/Neutral Site | 7 | 38 | 369 | 5.4 | 52.7 |
| in Wins | 7 | 35 | 265 | 5.0 | 37.9 |
| in Losses | 6 | 33 | 357 | 5.5 | 59.5 |
| vs. Conference | 9 | 47 | 437 | 5.2 | 48.6 |
| vs. Non-Conference | 4 | 21 | 185 | 5.3 | 46.3 |
| vs. Ranked (AP) | 5 | 30 | 324 | 6.0 | 64.8 |
| vs. Unranked (AP) | 8 | 38 | 298 | 4.8 | 37.3 |
| vs. FBS (I-A) | 12 | 63 | 594 | 5.3 | 49.5 |
| vs. FCS (I-AA) | 1 | 5 | 28 | 5.0 | 28.0 |
| vs. FBS Winning | 7 | 39 | 389 | 5.6 | 55.6 |
| vs. FBS Non-Winning | 5 | 24 | 205 | 4.8 | 41.0 |
| vs. FBS Power 5 | 11 | 57 | 547 | 5.2 | 49.7 |
| vs. FBS non-Power 5 | 1 | 6 | 47 | 6.0 | 47.0 |
| in August/September | 4 | 25 | 225 | 6.3 | 56.3 |
| in October | 4 | 18 | 157 | 4.5 | 39.3 |
| in November | 4 | 20 | 180 | 5.0 | 45.0 |
| in December/January | 1 | 5 | 60 | 5.0 | 60.0 |