2021 National Leaders Passes Defended - Games vs. Ranked Teams Only (AP Poll) through 01/10/2022
| Name | Team | Yr | Pos | G | Int. | Passes Broken Up | Passes Defended | Passes Defended/G | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Roger McCreary | Auburn | SR | CB | 4 | 0 | 10 | 10 | 2.50 |
| 2 | Faion Hicks | Wisconsin | SR | CB | 3 | 0 | 8 | 8 | 2.67 |
| 3 | Cam Taylor-Britt | Nebraska | JR | CB | 5 | 0 | 7 | 7 | 1.40 |
| 4 | Clark Phillips III | Utah | FR | CB | 5 | 1 | 5 | 6 | 1.20 |
| 4 | Jaylin Williams | Indiana | SR | DB | 5 | 0 | 6 | 6 | 1.20 |
| 6 | Kaonohi Kaniho | Boise St | FR | CB | 2 | 1 | 4 | 5 | 2.50 |
| 6 | Erick Hallett II | Pittsburgh | JR | DB | 3 | 2 | 3 | 5 | 1.67 |
| 6 | Verone McKinley III | Oregon | SO | S | 4 | 2 | 3 | 5 | 1.25 |
| 6 | Denzel Burke | Ohio State | FR | CB | 4 | 0 | 5 | 5 | 1.25 |
| 6 | Jarrick Bernard-Converse | Okla St | SR | CB | 4 | 0 | 5 | 5 | 1.25 |
| 6 | JT Woods | Baylor | SR | S | 5 | 4 | 1 | 5 | 1.00 |
| 6 | Christopher Smith | Georgia | SR | DB | 5 | 2 | 3 | 5 | 1.00 |
| 6 | Theo Jackson | Tennessee | SR | DB | 5 | 0 | 5 | 5 | 1.00 |
| 14 | Jermari Harris | Iowa | SO | DB | 2 | 2 | 2 | 4 | 2.00 |
| 14 | Evan Williams | Fresno St | JR | DB | 2 | 1 | 3 | 4 | 2.00 |
| 14 | Tayler Hawkins | SDSU | SR | CB | 2 | 1 | 3 | 4 | 2.00 |
| 14 | Damarri Mathis | Pittsburgh | SR | DB | 2 | 1 | 3 | 4 | 2.00 |
| 14 | Bobby Brown, II | SJSU | SR | DB | 2 | 0 | 4 | 4 | 2.00 |
| 14 | Woodi Washington | Oklahoma | SO | CB | 3 | 2 | 2 | 4 | 1.33 |
| 14 | Cam Smith | S Carolina | SO | DB | 3 | 1 | 3 | 4 | 1.33 |
| 14 | Bryan Cook | Cincinnati | SR | S | 3 | 1 | 3 | 4 | 1.33 |
| 14 | Chris Steele | USC | JR | CB | 3 | 1 | 3 | 4 | 1.33 |
| 14 | Brandon Hill | Pittsburgh | SO | DB | 3 | 1 | 3 | 4 | 1.33 |
| 14 | A.J. Woods | Pittsburgh | JR | DB | 3 | 1 | 3 | 4 | 1.33 |
| 14 | Kei'Trel Clark | Louisville | SO | DB | 3 | 0 | 4 | 4 | 1.33 |
| 14 | Allan George | Vanderbilt | SR | CB | 3 | 0 | 4 | 4 | 1.33 |
| 14 | Syrus Dumas | NMSU | SO | DB | 3 | 0 | 4 | 4 | 1.33 |
| 14 | Cam'Ron Kelly | N Carolina | JR | DB | 4 | 2 | 2 | 4 | 1.00 |
| 14 | Andrew Booth Jr. | Clemson | JR | CB | 4 | 1 | 3 | 4 | 1.00 |
| 14 | Josh Sanguinetti | Indiana | SO | DB | 4 | 1 | 3 | 4 | 1.00 |
| 14 | JoJo Domann | Nebraska | SR | OLB | 4 | 1 | 3 | 4 | 1.00 |
| 14 | Malcolm Rodriguez | Okla St | SR | LB | 4 | 1 | 3 | 4 | 1.00 |
| 14 | Darian Chestnut | Syracuse | FR | DB | 4 | 1 | 3 | 4 | 1.00 |
| 14 | DaMarcus Fields | Texas Tech | SR | DB | 4 | 0 | 4 | 4 | 1.00 |
| 14 | Treydan Stukes | Arizona | FR | CB | 4 | 0 | 4 | 4 | 1.00 |
| 14 | Jaylon Monroe | Tulane | SR | CB | 4 | 0 | 4 | 4 | 1.00 |
| 14 | Cameron Brown | Ohio State | JR | CB | 4 | 0 | 4 | 4 | 1.00 |
| 14 | Darrius Bratton | Virginia | SR | CB | 4 | 0 | 4 | 4 | 1.00 |
| 14 | Tarheeb Still | Maryland | SO | DB | 4 | 0 | 4 | 4 | 1.00 |
| 14 | Zakoby McClain | Auburn | SR | LB | 4 | 0 | 4 | 4 | 1.00 |
| 14 | B.J. Foster | Texas | SR | DB | 5 | 3 | 1 | 4 | 0.80 |
| 14 | Jalen Green | Miss St | SR | S | 5 | 2 | 2 | 4 | 0.80 |
| 14 | Al Walcott | Baylor | JR | CB | 5 | 2 | 2 | 4 | 0.80 |
| 14 | Raleigh Texada | Baylor | SR | CB | 5 | 1 | 3 | 4 | 0.80 |
| 14 | Chandler Jones | Louisville | JR | DB | 5 | 0 | 4 | 4 | 0.80 |
| 14 | Luke Reimer | Nebraska | SO | ILB | 5 | 0 | 4 | 4 | 0.80 |
| 14 | Quinton Newsome | Nebraska | SO | CB | 5 | 0 | 4 | 4 | 0.80 |
| 14 | Brian Branch | Alabama | SO | DB | 5 | 0 | 4 | 4 | 0.80 |
| 14 | Derion Kendrick | Georgia | SR | DB | 6 | 2 | 2 | 4 | 0.67 |
| 14 | Lewis Cine | Georgia | JR | DB | 6 | 0 | 4 | 4 | 0.67 |
| 51 | Cole Godbout | Wyoming | JR | NT | 1 | 0 | 3 | 3 | 3.00 |
| 51 | Micah Abraham | Marshall | SO | DB | 1 | 0 | 3 | 3 | 3.00 |
| 51 | Warren Saba | ECU | SR | SAF | 2 | 2 | 1 | 3 | 1.50 |
| 51 | Corvan Taylor | Air Force | SR | SS | 2 | 1 | 2 | 3 | 1.50 |
| 51 | Trenton Thompson | SDSU | SR | S | 2 | 0 | 3 | 3 | 1.50 |
| 51 | Kaiir Elam | Florida | JR | CB | 2 | 0 | 3 | 3 | 1.50 |
| 51 | Seth Robertson | Ga South | SO | CB | 2 | 0 | 3 | 3 | 1.50 |
| 51 | Kaleb Hayes | BYU | JR | DB | 2 | 0 | 3 | 3 | 1.50 |
| 51 | Shaun Jolly | App St | SR | DB | 2 | 0 | 3 | 3 | 1.50 |
| 51 | Jaylan Foster | S Carolina | SR | DB | 3 | 3 | 0 | 3 | 1.00 |
| 51 | Payton Wilgar | BYU | SO | LB | 3 | 1 | 2 | 3 | 1.00 |
| 51 | Jakob Robinson | BYU | FR | DB | 3 | 1 | 2 | 3 | 1.00 |
| 51 | Tre'Vez Johnson | Florida | SO | S | 3 | 1 | 2 | 3 | 1.00 |
| 51 | Miles Battle | Miss | JR | DB | 3 | 1 | 2 | 3 | 1.00 |
| 51 | Gabe Reid | Stanford | SR | OLB | 3 | 1 | 2 | 3 | 1.00 |
| 51 | Anthony Wilson | Ga South | SO | S | 3 | 0 | 3 | 3 | 1.00 |
| 51 | Tre Avery | Rutgers | SR | DB | 3 | 0 | 3 | 3 | 1.00 |
| 51 | Antonio Johnson | Texas A&M | SO | DB | 3 | 0 | 3 | 3 | 1.00 |
| 51 | Montaric Brown | Arkansas | SR | DB | 3 | 0 | 3 | 3 | 1.00 |
| 51 | Coby Bryant | Cincinnati | SR | CB | 3 | 0 | 3 | 3 | 1.00 |
| 51 | Deane Leonard | Miss | SR | DB | 3 | 0 | 3 | 3 | 1.00 |
| 51 | CJ Burton | BC | FR | DB | 3 | 0 | 3 | 3 | 1.00 |
| 51 | Kyu Blu Kelly | Stanford | JR | CB | 3 | 0 | 3 | 3 | 1.00 |
| 51 | Cam Allen | Purdue | JR | S | 4 | 2 | 1 | 3 | 0.75 |
| 51 | Anthony Johnson | Virginia | JR | DB | 4 | 2 | 1 | 3 | 0.75 |
| 51 | Jadon Canady | Tulane | FR | DB | 4 | 1 | 2 | 3 | 0.75 |
| 51 | Caleb Mills | NMSU | SR | DB | 4 | 1 | 2 | 3 | 0.75 |
| 51 | TieNeal Martin | Tulsa | SR | S | 4 | 1 | 2 | 3 | 0.75 |
| 51 | Tyreque Jones | Boise St | SR | S | 4 | 1 | 2 | 3 | 0.75 |
| 51 | Kalon Barnes | Baylor | SR | CB | 4 | 1 | 2 | 3 | 0.75 |
| 51 | R.J. Moten | Michigan | SO | DB | 4 | 1 | 2 | 3 | 0.75 |
| 51 | Mario Goodrich | Clemson | SR | CB | 4 | 0 | 3 | 3 | 0.75 |
| 51 | Andrew Mukuba | Clemson | FR | S | 4 | 0 | 3 | 3 | 0.75 |
| 51 | Justus Rogers | Wash St | SR | LB | 4 | 0 | 3 | 3 | 0.75 |
| 51 | Colin Schooler | Texas Tech | SR | LB | 4 | 0 | 3 | 3 | 0.75 |
| 51 | Rayshad Williams | Texas Tech | JR | DB | 4 | 0 | 3 | 3 | 0.75 |
| 51 | Christian Young | Arizona | JR | VPR | 4 | 0 | 3 | 3 | 0.75 |
| 51 | Ajani Kerr | Tulane | SR | DB | 4 | 0 | 3 | 3 | 0.75 |
| 51 | Zach Harrison | Ohio State | JR | DE | 4 | 0 | 3 | 3 | 0.75 |
| 51 | Cole Bishop | Utah | FR | S | 4 | 0 | 3 | 3 | 0.75 |
| 51 | Warren Burrell | Tennessee | JR | DB | 4 | 0 | 3 | 3 | 0.75 |
| 51 | Jamari Brown | Purdue | JR | CB | 4 | 0 | 3 | 3 | 0.75 |
| 51 | JL Skinner | Boise St | JR | S | 4 | 0 | 3 | 3 | 0.75 |
| 51 | Coen King | Virginia | JR | DB | 4 | 0 | 3 | 3 | 0.75 |
| 51 | Tanner McCalister | Okla St | SR | S | 4 | 0 | 3 | 3 | 0.75 |
| 51 | Christian Holmes | Okla St | SR | CB | 4 | 0 | 3 | 3 | 0.75 |
| 51 | Garrett Williams | Syracuse | FR | DB | 4 | 0 | 3 | 3 | 0.75 |
| 51 | Dwight McGlothern | LSU | SO | CB | 4 | 0 | 3 | 3 | 0.75 |
| 51 | Myles Murphy | N Carolina | SO | DL | 4 | 0 | 3 | 3 | 0.75 |
| 51 | Tony Grimes | N Carolina | SO | DB | 4 | 0 | 3 | 3 | 0.75 |