2021 Mid-American Conference Leaders Rushing Defense - Games vs. Unranked Teams Only (AP Poll) through 01/10/2022
| Name | G | Att | Yards | Avg. | TD | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Toledo | 12 | 486 | 1837 | 3.78 | 10 | 40.50 | 153.08 |
| 2 | Western Michigan | 11 | 353 | 1476 | 4.18 | 14 | 32.09 | 134.18 |
| 3 | Miami (Ohio) | 12 | 451 | 1650 | 3.66 | 15 | 37.58 | 137.50 |
| 4 | Central Michigan | 13 | 463 | 1551 | 3.35 | 18 | 35.62 | 119.31 |
| 5 | Ohio | 11 | 429 | 2006 | 4.68 | 20 | 39.00 | 182.36 |
| 6 | Ball State | 13 | 528 | 2293 | 4.34 | 22 | 40.62 | 176.38 |
| 7 | Northern Illinois | 13 | 469 | 2630 | 5.61 | 25 | 36.08 | 202.31 |
| 8 | Buffalo | 12 | 489 | 2339 | 4.78 | 27 | 40.75 | 194.92 |
| 8 | Eastern Michigan | 13 | 508 | 2599 | 5.12 | 27 | 39.08 | 199.92 |
| 8 | Akron | 11 | 447 | 2750 | 6.15 | 27 | 40.64 | 250.00 |
| 11 | Bowling Green | 12 | 542 | 2254 | 4.16 | 30 | 45.17 | 187.83 |
| 12 | Kent State | 13 | 541 | 2676 | 4.95 | 37 | 41.62 | 205.85 |