2021 Mid-American Conference Leaders Total Defense - Games at Home Only through 01/10/2022
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Miami (Ohio) | 5 | 424 | 1197 | 333 | 1621 | 4.87 | 324.2 |
| 2 | Western Michigan | 6 | 509 | 1184 | 347 | 1693 | 4.88 | 282.2 |
| 3 | Buffalo | 6 | 1219 | 1125 | 366 | 2344 | 6.40 | 390.7 |
| 4 | Akron | 6 | 1485 | 936 | 386 | 2421 | 6.27 | 403.5 |
| 5 | Northern Illinois | 6 | 1059 | 1406 | 392 | 2465 | 6.29 | 410.8 |
| 6 | Eastern Michigan | 6 | 986 | 1403 | 397 | 2389 | 6.02 | 398.2 |
| 7 | Bowling Green | 6 | 819 | 1355 | 398 | 2174 | 5.46 | 362.3 |
| 8 | Central Michigan | 6 | 572 | 1552 | 399 | 2124 | 5.32 | 354.0 |
| 9 | Ohio | 6 | 1183 | 1450 | 415 | 2633 | 6.34 | 438.8 |
| 10 | Ball State | 6 | 1114 | 1259 | 422 | 2373 | 5.62 | 395.5 |
| 10 | Kent State | 5 | 780 | 1583 | 422 | 2363 | 5.60 | 472.6 |
| 12 | Toledo | 6 | 1084 | 1165 | 431 | 2249 | 5.22 | 374.8 |