2021 Big Ten Conference Leaders Opponent First Downs - Games vs. FBS Power 5 Conference Teams Only through 01/10/2022
| Name | G | Rush | Pass | Penalty | Total | Total/G | |
|---|---|---|---|---|---|---|---|
| 1 | Wisconsin | 10 | 41 | 80 | 15 | 136 | 13.6 |
| 2 | Minnesota | 11 | 75 | 83 | 12 | 170 | 15.5 |
| 3 | Michigan | 12 | 84 | 115 | 12 | 211 | 17.6 |
| 4 | Iowa | 12 | 84 | 119 | 18 | 221 | 18.4 |
| 5 | Purdue | 11 | 98 | 98 | 16 | 212 | 19.3 |
| 6 | Nebraska | 10 | 80 | 105 | 14 | 199 | 19.9 |
| 7 | Rutgers | 11 | 98 | 107 | 21 | 226 | 20.5 |
| 8 | Illinois | 10 | 100 | 97 | 12 | 209 | 20.9 |
| 9 | Indiana | 9 | 77 | 100 | 15 | 192 | 21.3 |
| 10 | Ohio State | 11 | 87 | 126 | 22 | 235 | 21.4 |
| 11 | Maryland | 11 | 99 | 116 | 23 | 238 | 21.6 |
| 11 | Penn State | 11 | 115 | 99 | 24 | 238 | 21.6 |
| 13 | Northwestern | 10 | 112 | 104 | 12 | 228 | 22.8 |
| 14 | Michigan State | 11 | 85 | 160 | 21 | 266 | 24.2 |