2021 American Athletic Conference Leaders Total Defense - Games vs. FBS Power 5 Conference Teams Only through 01/10/2022
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Temple | 2 | 399 | 204 | 133 | 603 | 4.53 | 301.5 |
| 2 | East Carolina | 1 | 99 | 225 | 63 | 324 | 5.14 | 324.0 |
| 3 | Cincinnati | 2 | 453 | 405 | 152 | 858 | 5.64 | 429.0 |
| 3 | Memphis | 1 | 49 | 419 | 83 | 468 | 5.64 | 468.0 |
| 5 | Tulsa | 2 | 459 | 358 | 135 | 817 | 6.05 | 408.5 |
| 6 | UCF | 2 | 396 | 481 | 143 | 877 | 6.13 | 438.5 |
| 7 | Houston | 2 | 270 | 458 | 118 | 728 | 6.17 | 364.0 |
| 8 | Tulane | 2 | 488 | 649 | 169 | 1137 | 6.73 | 568.5 |
| 9 | SMU | 1 | 170 | 276 | 58 | 446 | 7.69 | 446.0 |
| 10 | South Florida | 2 | 656 | 535 | 135 | 1191 | 8.82 | 595.5 |