2021 American Athletic Conference Leaders Interceptions - Games vs. Ranked Teams Only (AP Poll) through 01/10/2022
| Name | Team | Yr | Pos | G | Int. | Yards | TD | Int./G | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Christian Williams | S Florida | SO | S | 3 | 1 | 61 | 0 | 0.33 |
| 2 | Justin Wright | Tulsa | JR | LB | 4 | 1 | 55 | 1 | 0.25 |
| 3 | Macon Clark | Tulane | JR | S | 4 | 2 | 33 | 0 | 0.50 |
| 4 | Deshawn Pace | Cincinnati | SO | LB | 3 | 1 | 27 | 0 | 0.33 |
| 4 | Matthew Hill | S Florida | SO | S | 3 | 1 | 27 | 0 | 0.33 |
| 6 | Rodney Owens | Memphis | SR | DB | 1 | 1 | 25 | 0 | 1.00 |
| 7 | Joel Dublanko | Cincinnati | SR | LB | 3 | 1 | 9 | 0 | 0.33 |
| 8 | Ahmad Gardner | Cincinnati | JR | CB | 3 | 1 | 4 | 0 | 0.33 |
| 9 | Jamal Glenn | Navy | SR | CB | 3 | 1 | 1 | 0 | 0.33 |