2021 Atlantic Coast Conference Leaders Turnover Margin - Games vs. Unranked Teams Only (AP Poll) through 01/10/2022
| Name | G | Fum. Gain | Int. Gain | Total Gain | Fum. Lost | Int. Lost | Total Lost | Margin | Margin/G | |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Louisville | 8 | 4 | 9 | 13 | 4 | 3 | 7 | 6 | 0.75 |
| 1 | Virginia Tech | 11 | 4 | 8 | 12 | 6 | 3 | 9 | 3 | 0.27 |
| 3 | North Carolina State | 10 | 1 | 11 | 12 | 3 | 4 | 7 | 5 | 0.50 |
| 3 | Syracuse | 8 | 3 | 2 | 5 | 4 | 4 | 8 | -3 | -0.38 |
| 5 | Florida State | 8 | 3 | 10 | 13 | 4 | 5 | 9 | 4 | 0.50 |
| 5 | Miami (Florida) | 8 | 2 | 6 | 8 | 4 | 5 | 9 | -1 | -0.13 |
| 7 | Boston College | 9 | 7 | 9 | 16 | 4 | 6 | 10 | 6 | 0.67 |
| 7 | Georgia Tech | 8 | 9 | 3 | 12 | 4 | 6 | 10 | 2 | 0.25 |
| 7 | Clemson | 9 | 3 | 10 | 13 | 6 | 6 | 12 | 1 | 0.11 |
| 7 | North Carolina | 9 | 3 | 8 | 11 | 4 | 6 | 10 | 1 | 0.11 |
| 7 | Virginia | 8 | 5 | 5 | 10 | 4 | 6 | 10 | 0 | 0.00 |
| 12 | Wake Forest | 11 | 11 | 12 | 23 | 3 | 7 | 10 | 13 | 1.18 |
| 12 | Pittsburgh | 11 | 6 | 9 | 15 | 6 | 7 | 13 | 2 | 0.18 |
| 14 | Duke | 10 | 3 | 8 | 11 | 10 | 8 | 18 | -7 | -0.70 |