2021 Atlantic Coast Conference Leaders Long All Purpose Plays - Games vs. Conference Teams Only through 01/10/2022
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| Name | Team | Yr | Pos | G | Yards | Yards | Yards | Yards | Yards | Yards | Yards | |
| 1 | Jahmyr Gibbs | Ga Tech | FR | RB | 8 | 9 | 6 | 6 | 5 | 4 | 1 | 1 |
| 2 | Zonovan Knight | NC State | SO | RB | 8 | 4 | 3 | 3 | 3 | 3 | 2 | 2 |
| 3 | Ty Chandler | N Carolina | SR | RB | 9 | 6 | 4 | 4 | 2 | 1 | 0 | 0 |
| 3 | Tyler Harrell | Louisville | SO | WR | 8 | 8 | 4 | 3 | 2 | 2 | 1 | 1 |
| 3 | A.T. Perry | Wk Forest | SO | WR | 10 | 10 | 6 | 3 | 2 | 0 | 0 | 0 |
| 3 | Charleston Rambo | Miami (Fl) | JR | WR | 8 | 11 | 4 | 2 | 2 | 0 | 0 | 0 |
| 3 | Jaylen Stinson | Duke | SO | S | 8 | 3 | 2 | 2 | 2 | 2 | 2 | 1 |
| 3 | Tré Turner | Va Tech | JR | WR | 7 | 5 | 3 | 2 | 2 | 0 | 0 | 0 |
| 9 | Israel Abanikanda | Pittsburgh | SO | RB | 8 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| 9 | Jordan Addison | Pittsburgh | SO | WR | 9 | 12 | 5 | 1 | 1 | 0 | 0 | 0 |
| 9 | Khafre Brown | N Carolina | SO | WR | 5 | 1 | 1 | 1 | 1 | 1 | 0 | 0 |
| 9 | Braxton Burmeister | Va Tech | JR | QB | 8 | 1 | 1 | 1 | 1 | 1 | 0 | 0 |
| 9 | Jalon Calhoun | Duke | JR | WR | 8 | 4 | 1 | 1 | 1 | 1 | 1 | 0 |
| 9 | Jashaun Corbin | FSU | SO | RB | 8 | 2 | 1 | 1 | 1 | 1 | 0 | 0 |
| 9 | Malik Cunningham | Louisville | JR | QB | 8 | 4 | 3 | 2 | 1 | 1 | 0 | 0 |
| 9 | Fentrell Cypress II | Virginia | SO | DB | 5 | 1 | 1 | 1 | 1 | 0 | 0 | 0 |
| 9 | Josh Downs | N Carolina | SO | WR | 9 | 10 | 4 | 2 | 1 | 0 | 0 | 0 |
| 9 | Justice Ellison | Wk Forest | FR | RB | 8 | 2 | 1 | 1 | 1 | 0 | 0 | 0 |
| 9 | Emeka Emezie | NC State | SR | WR | 8 | 2 | 2 | 1 | 1 | 0 | 0 | 0 |
| 9 | Antoine Green | N Carolina | SR | WR | 9 | 3 | 2 | 1 | 1 | 1 | 0 | 0 |
| 9 | Courtney Jackson | Syracuse | FR | WR | 8 | 1 | 1 | 1 | 1 | 0 | 0 | 0 |
| 9 | Jaylan Knighton | Miami (Fl) | FR | RB | 8 | 4 | 3 | 2 | 1 | 0 | 0 | 0 |
| 9 | Phil Mafah | Clemson | FR | RB | 6 | 1 | 1 | 1 | 1 | 0 | 0 | 0 |
| 9 | Jordan Mason | Ga Tech | JR | RB | 8 | 1 | 1 | 1 | 1 | 1 | 0 | 0 |
| 9 | Trey Morrison | N Carolina | SR | DB | 9 | 1 | 1 | 1 | 1 | 0 | 0 | 0 |
| 9 | Trebor Pena | Syracuse | FR | WR | 4 | 3 | 2 | 2 | 1 | 0 | 0 | 0 |
| 9 | C.J. Riley | NC State | SR | WR | 8 | 1 | 1 | 1 | 1 | 0 | 0 | 0 |
| 9 | Tayvion Robinson | Va Tech | SO | WR | 8 | 5 | 4 | 1 | 1 | 0 | 0 | 0 |
| 9 | Will Shipley | Clemson | FR | RB | 6 | 3 | 2 | 1 | 1 | 1 | 0 | 0 |
| 9 | Emery Simmons | N Carolina | JR | WR | 6 | 2 | 1 | 1 | 1 | 0 | 0 | 0 |
| 9 | Brashard Smith | Miami (Fl) | FR | WR | 8 | 1 | 1 | 1 | 1 | 1 | 0 | 0 |
| 9 | Thayer Thomas | NC State | JR | WR | 8 | 2 | 2 | 1 | 1 | 1 | 0 | 0 |
| 9 | Lawrance Toafili | FSU | FR | RB | 5 | 1 | 1 | 1 | 1 | 1 | 0 | 0 |
| 9 | Treshaun Ward | FSU | FR | RB | 8 | 2 | 1 | 1 | 1 | 0 | 0 | 0 |
| 9 | Jordan Watkins | Louisville | FR | WR | 8 | 4 | 2 | 1 | 1 | 1 | 0 | 0 |
| 9 | Dontayvion Wicks | Virginia | SO | WR | 8 | 7 | 3 | 1 | 1 | 1 | 0 | 0 |
| 9 | Ontaria Wilson | FSU | JR | WR | 8 | 4 | 2 | 1 | 1 | 0 | 0 | 0 |
| 9 | A.J. Woods | Pittsburgh | JR | DB | 8 | 1 | 1 | 1 | 1 | 1 | 0 | 0 |