2021 Mountain West Conference Leaders Total Defense - Games vs. Ranked Teams Only (AP Poll) through 01/10/2022
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Colorado State | 2 | 165 | 457 | 133 | 622 | 4.68 | 311.0 |
| 2 | San Jose State | 2 | 217 | 433 | 147 | 650 | 4.42 | 325.0 |
| 3 | Nevada | 1 | 186 | 176 | 73 | 362 | 4.96 | 362.0 |
| 3 | Wyoming | 1 | 181 | 181 | 73 | 362 | 4.96 | 362.0 |
| 5 | UNLV | 2 | 240 | 490 | 135 | 730 | 5.41 | 365.0 |
| 6 | San Diego State | 2 | 162 | 575 | 160 | 737 | 4.61 | 368.5 |
| 7 | Fresno State | 2 | 351 | 419 | 144 | 770 | 5.35 | 385.0 |
| 8 | New Mexico | 2 | 319 | 457 | 127 | 776 | 6.11 | 388.0 |
| 9 | Utah State | 2 | 369 | 412 | 133 | 781 | 5.87 | 390.5 |
| 10 | Hawai'i | 2 | 286 | 505 | 145 | 791 | 5.46 | 395.5 |
| 11 | Boise State | 4 | 710 | 874 | 281 | 1584 | 5.64 | 396.0 |
| 12 | Air Force | 2 | 337 | 520 | 141 | 857 | 6.08 | 428.5 |