2021 Big 12 Conference Leaders Total Defense - All Games through 01/10/2022
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Oklahoma State | 14 | 1227 | 2943 | 910 | 4170 | 4.58 | 297.9 |
| 2 | Iowa State | 13 | 1590 | 2435 | 798 | 4025 | 5.04 | 309.6 |
| 3 | Kansas State | 13 | 1686 | 2798 | 835 | 4484 | 5.37 | 344.9 |
| 4 | Baylor | 14 | 1652 | 3192 | 941 | 4844 | 5.15 | 346.0 |
| 5 | West Virginia | 13 | 1804 | 2750 | 821 | 4554 | 5.55 | 350.3 |
| 6 | Oklahoma | 13 | 1677 | 3403 | 887 | 5080 | 5.73 | 390.8 |
| 7 | Texas Tech | 13 | 1786 | 3487 | 899 | 5273 | 5.87 | 405.6 |
| 8 | Texas | 12 | 2419 | 2688 | 847 | 5107 | 6.03 | 425.6 |
| 9 | TCU | 12 | 2664 | 2877 | 768 | 5541 | 7.21 | 461.8 |
| 10 | Kansas | 12 | 2998 | 2837 | 809 | 5835 | 7.21 | 486.3 |