2021 Conference USA Leaders Tackles For Loss - Games vs. Non-Conference Teams Only through 01/10/2022
| Name | G | TFL | TFL Yards | TFL/G | |
|---|---|---|---|---|---|
| 1 | North Texas | 5 | 39.0 | 168 | 7.80 |
| 2 | Marshall | 5 | 45.0 | 167 | 9.00 |
| 3 | Southern Mississippi | 4 | 31.0 | 124 | 7.75 |
| 4 | Western Kentucky | 5 | 26.0 | 118 | 5.20 |
| 5 | Middle Tennessee | 5 | 34.0 | 117 | 6.80 |
| 6 | Old Dominion | 5 | 28.0 | 111 | 5.60 |
| 7 | UTSA | 5 | 30.0 | 107 | 6.00 |
| 7 | UTEP | 5 | 28.0 | 107 | 5.60 |
| 9 | Charlotte | 4 | 24.0 | 99 | 6.00 |
| 10 | Florida International | 4 | 22.0 | 77 | 5.50 |
| 11 | Rice | 4 | 16.0 | 71 | 4.00 |
| 12 | UAB | 5 | 20.0 | 67 | 4.00 |
| 13 | Louisiana Tech | 4 | 13.0 | 65 | 3.25 |
| 14 | Florida Atlantic | 4 | 17.0 | 64 | 4.25 |