2021 Conference USA Leaders Penalties - Games vs. Non-Conference Teams Only through 01/10/2022
| Name | G | Pen. | Yards | Pen./G | Yards/G | |
|---|---|---|---|---|---|---|
| 1 | UTSA | 5 | 21 | 209 | 4.2 | 41.8 |
| 2 | Charlotte | 4 | 23 | 182 | 5.8 | 45.5 |
| 3 | Florida International | 4 | 25 | 230 | 6.3 | 57.5 |
| 4 | Florida Atlantic | 4 | 27 | 200 | 6.8 | 50.0 |
| 4 | Southern Mississippi | 4 | 27 | 219 | 6.8 | 54.8 |
| 6 | Louisiana Tech | 4 | 28 | 184 | 7.0 | 46.0 |
| 7 | Rice | 4 | 29 | 225 | 7.3 | 56.3 |
| 8 | Western Kentucky | 5 | 32 | 233 | 6.4 | 46.6 |
| 8 | Middle Tennessee | 5 | 32 | 257 | 6.4 | 51.4 |
| 10 | Old Dominion | 5 | 35 | 305 | 7.0 | 61.0 |
| 11 | Marshall | 5 | 36 | 337 | 7.2 | 67.4 |
| 12 | North Texas | 5 | 37 | 350 | 7.4 | 70.0 |
| 13 | UAB | 5 | 39 | 356 | 7.8 | 71.2 |
| 14 | UTEP | 5 | 45 | 432 | 9.0 | 86.4 |