2021 Conference USA Leaders Total Defense - Games in December/January Only through 01/10/2022
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | UAB | 1 | 199 | 195 | 58 | 394 | 6.79 | 394.0 |
| 2 | North Texas | 1 | 203 | 230 | 78 | 433 | 5.55 | 433.0 |
| 3 | Middle Tennessee | 1 | 235 | 212 | 71 | 447 | 6.30 | 447.0 |
| 4 | UTEP | 1 | 181 | 286 | 76 | 467 | 6.14 | 467.0 |
| 5 | Marshall | 1 | 220 | 278 | 83 | 498 | 6.00 | 498.0 |
| 6 | UTSA | 2 | 147 | 910 | 152 | 1057 | 6.95 | 528.5 |
| 7 | Old Dominion | 1 | 244 | 285 | 99 | 529 | 5.34 | 529.0 |
| 8 | Western Kentucky | 2 | 565 | 610 | 162 | 1175 | 7.25 | 587.5 |