2021 Conference USA Leaders Scoring Defense - Games Won Only through 01/10/2022
| Name | G | TD | FG | 1XP | 2XP | Safety | Points | Points/G | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Florida International | 1 | 1 | 1 | 1 | 0 | 0 | 10 | 10.0 |
| 2 | Southern Mississippi | 3 | 3 | 5 | 3 | 0 | 0 | 36 | 12.0 |
| 3 | Marshall | 7 | 11 | 5 | 11 | 0 | 0 | 92 | 13.1 |
| 4 | Florida Atlantic | 5 | 10 | 2 | 7 | 1 | 0 | 75 | 15.0 |
| 5 | UTEP | 7 | 14 | 4 | 13 | 0 | 0 | 109 | 15.6 |
| 6 | UAB | 9 | 20 | 2 | 18 | 1 | 0 | 146 | 16.2 |
| 7 | North Texas | 6 | 12 | 5 | 12 | 0 | 0 | 99 | 16.5 |
| 8 | Middle Tennessee | 7 | 14 | 6 | 13 | 1 | 0 | 117 | 16.7 |
| 9 | Old Dominion | 6 | 14 | 7 | 13 | 0 | 0 | 118 | 19.7 |
| 10 | Western Kentucky | 9 | 25 | 6 | 23 | 0 | 0 | 191 | 21.2 |
| 11 | UTSA | 12 | 33 | 12 | 26 | 1 | 0 | 262 | 21.8 |
| 12 | Charlotte | 5 | 17 | 5 | 15 | 1 | 0 | 134 | 26.8 |
| 13 | Rice | 4 | 13 | 5 | 13 | 0 | 1 | 108 | 27.0 |
| 14 | Louisiana Tech | 3 | 12 | 2 | 11 | 1 | 0 | 91 | 30.3 |